IP Library › Granted Patent US 10,377,748
Granted Patent B2
US 10,377,748 · App. 15/760,284 · Granted Aug 13, 2019

Hepatitis B core protein modulators

Inventors: William Turner (Bloomington, IN); Lee Daniel Arnold (Bloomington, IN); Hans Maag (Kleires Wiesental, DE); Leping Li (Carmel, IN); Mark Bures (Carmel, IN); Simon Haydar (Carmel, IN); Samson Francis (Indianapolis, IN)
Assignees: Assembly Biosciences, Inc.; Indiana University Research And Technology Corporation
C07D417/12A61K45/06A61P31/20C07D243/38C07D267/20C07D281/16C07D401/12C07D403/12C07D413/12C07D417/14C07D453/02C07D471/04
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Quick Facts
Patent No.
US 10,377,748
App. No.
15/760,284
Granted
Aug 13, 2019
Kind
B2
Abstract

The present disclosure provides, in part, compounds having allosteric effector properties against Hepatitis B virus Cp. Also provided herein are methods of treating viral infections, such as hepatitis B, comprising administering to a patient in need thereof a disclosed compound.

Claims (4)

1. A compound having the following formula:

or a pharmaceutically acceptable salt thereof.

2. A pharmaceutically acceptable composition comprising the compound of claim 1 , and a pharmaceutically acceptable excipient.

3. A method of treating a hepatitis B infection in a patient in need thereof, comprising administering to said patient an effective amount of the compound of claim 1 , or a pharmaceutically acceptable salt thereof.

Assignments (5)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 15, 2023
From: ARNOLD, LEE D.; MAAG, HANS; LI, LEPING; BURES, MARK G.; HAYDAR, SIMON NICOLAS; FRANCIS, SAMSON
To: ASSEMBLY BIOSCIENCES, INC.
Reel/Frame 064919/0755 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 15, 2023
From: TURNER, JR., WILLIAM W.
To: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
Reel/Frame 064919/0828 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 21, 2022
From: TURNER, JR., WILLIAM W.
To: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
Reel/Frame 061839/0561 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Nov 21, 2022
From: ARNOLD, LEE D.; MAAG, HANS; LI, LEPING; BURES, MARK G.; HAYDAR, SIMON NICOLAS; FRANCIS, SAMSON
To: ASSEMBLY BIOSCIENCES, INC.
Reel/Frame 061839/0568 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 21, 2018
From: TURNER, WILLIAM
To: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION
Reel/Frame 046645/0320 →
Continuity (2)
Provisional Application 62218815 · Sep 15, 2015
Related Publication 20180258084A1 · Sep 13, 2018