Methods of treating a retroviral infection
The invention relates to a non-coding sequence of deoxyribonucleic acids comprising at least one sequence motif N 1 N 2 CGN 3 N 4 , wherein N is a nucleotide comprising A, C, T, or G, and C is deoxycytidine, G is deoxyguanosine, A is deoxyadenosine and T is deoxy-thymidine for the treatment of viral infections. In particular, the non-coding sequence of deoxyribonucleic acids is used in combination with antiretroviral therapy and/or histone de-acetylase inhibitors.
1. A method of treating a latent human immunodeficiency virus 1 (HIV-1) infection in a patient in need thereof, comprising administering to the patient a non-coding sequence of deoxyribonucleic acids comprising
(SEQ ID NO: 5)
CCTAGGGGTT ACCACCTTCA TTGGAAAACG TTCTTCGGGG
CGTTCTTAGG TGGTAACC CCTAGGGGTT ACCACCTTCA
TTGGAAAACG TTCTTCGGGG CGTTCTTAGG TGGTAACC
in combination with combination antiretroviral therapy.
2. The method of claim 1 , wherein the non-coding sequence of deoxyribonucleic acids has a length of up to 200 nucleotides.
3. The method of claim 1 , wherein the non-coding sequence of deoxyribonucleic acids has a length of 116 nucleotides.
4. The method of claim 1 , where the non-coding sequence of deoxyribonucleic acids is part of a single stranded region.
5. The method of claim 1 comprising administering the non-coding sequence of deoxyribonucleic acids simultaneously, alternating or successively with combination antiretroviral therapy.
6. The method of claim 5 , wherein the non-coding sequence of deoxyribonucleic acids is administered prior to combination antiretroviral therapy.
7. The method of claim 1 , wherein the non-coding sequence of deoxyribonucleic acids is administered as an adjuvant in therapeutic or prophylactic vaccination.