PSYCHIATRIC TREATMENT FOR PATIENTS WITH GENE POLYMORPHISMS
The disclosure provides methods for treating psychiatric diseases, such as schizophrenia, in patients with certain gene polymorphisms using antipsychotic drugs, such as risperidone and paliperidone.
1 . A method for treating a psychiatric disease in a human having an MC4R gene polymorphism, an HTR2C gene polymorphism, an HTR2A gene polymorphism, or a combination thereof, comprising administering a pharmaceutical composition comprising a therapeutically effective amount of (i) risperidone or a pharmaceutically acceptable salt thereof or (ii) paliperidone or a pharmaceutically acceptable salt thereof, to the human having the MC4R gene polymorphism, the HTR2C gene polymorphism, the HTR2A gene polymorphism, or the combination thereof, to treat the psychiatric disease.
2 . The method of claim 1 , wherein the human has a TT genotype; a CC genotype; or a CT/TT genotype.
3 . The method of claim 1 or 2 , wherein the MC4R gene polymorphism is a single nucleotide polymorphism; wherein the HTR2C gene polymorphism is a single nucleotide polymorphism; and wherein the HTR2A gene polymorphism is a single nucleotide polymorphism.
4 . The method of claim 1 or 2 , wherein the MC4R gene polymorphism is an rs17782313 single nucleotide polymorphism; wherein the HTR2C gene polymorphism is an rs3813929 single nucleotide polymorphism; and wherein the HTR2A gene polymorphism is an rs6313 single nucleotide polymorphism.
5 . The method of any one of claims 1 - 4 , wherein the psychiatric disease is schizophrenia, bipolar disorder, or autism.
6 . The method of claim 5 , wherein the schizophrenia is acute schizophrenia.
7 . The method of any one of claims 1 - 6 , wherein the method comprises administering the pharmaceutical composition to the human by oral administration, parenteral administration, or surgical implantation.
8 . The method of any one of claims 1 - 6 , wherein the method comprises administering the pharmaceutical composition by intramuscular administration or by subcutaneous administration.
9 . The method of any one of claims 1 - 8 , wherein the pharmaceutical composition further comprises a poly(lactide-co-glycolide) copolymer.
10 . The method of claim 9 , wherein the poly(lactide-co-glycolide) copolymer is a 50:50 to 95:5 poly(lactide-co-glycolide) copolymer.
11 . The method of any one of claims 1 - 10 , wherein the pharmaceutical composition further comprises N-methyl-2-pyrrolidone.
12 . The method of claim 9 or 10 , wherein the poly(lactide-co-glycolide) copolymer is in the form of microspheres.
13 . The method of any one of claims 1 - 8 , wherein the pharmaceutical composition comprises about 5 wt % to about 25 wt % risperidone base; about 25 wt/o to about 50 wt % of a poly(lactide-co-glycolide)copolymer; and about 35 wt % to about 60 wt % N-methyl-2-pyrrolidone.
14 . The method of any one of claims 1 - 8 , wherein the pharmaceutical composition comprises about 15 wt % risperidone base; about 38 wt % of an 80:20 poly(lactide-co-glycolide)copolymer having a number average molecular weight from about 20,000 Daltons to about 30,000 Daltons; and about 47 wt % N-methyl-2-pyrrolidone.
15 . A method for treating schizophrenia in a human having an MC4R gene polymorphism, an HTR2C gene polymorphism, an HTR2A gene polymorphism, or a combination thereof comprising subcutaneously administering once per month a pharmaceutical composition comprising a therapeutically effective amount of risperidone base, a poly(lactide-co-glycolide)copolymer, and N-methyl-2-pyrrolidone, to the human having the MC4R gene polymorphism, the HTR2C gene polymorphism, the HTR2A gene polymorphism, or the combination thereof, to treat the schizophrenia.
16 . The method of claim 15 , wherein the human has a TT genotype, a CC genotype, or a CT/TT genotype.
17 . The method of claim 15 or 16 , wherein the MC4R gene polymorphism is a single nucleotide polymorphism; wherein the HTR2C gene polymorphism is a single nucleotide polymorphism; and wherein the HTR2A gene polymorphism is a single nucleotide polymorphism.
18 . The method of claim 15 or 16 , wherein the MC4R gene polymorphism is an rs17782313 single nucleotide polymorphism; wherein the HTR2C gene polymorphism is an rs3813929 single nucleotide polymorphism; and wherein the HTR2A gene polymorphism is an rs6313 single nucleotide polymorphism.
19 . The method of any one of claims 15 - 18 , wherein the schizophrenia is acute schizophrenia.
20 . The method of any one of claims 15 - 18 , wherein the pharmaceutical composition comprises from about 60 grams to about 150 grams of risperidone base.
21 . The method of any one of claims 15 - 18 , wherein the pharmaceutical composition comprises about 5 wt % to about 25 wt %/o risperidone base; about 25 wt % to about 50 wt %/o of a poly(lactide-co-glycolide)copolymer; and about 35 wt % to about 60 wt % N-methyl-2-pyrrolidone.
22 . The method of any one of claims 15 - 18 , wherein the pharmaceutical composition comprises about 15 wt % risperidone base; about 38 wt % of an 80:20 poly(lactide-co-glycolide)copolymer having a number average molecular weight from about 20,000 Daltons to about 30,000 Daltons; and about 47 wt % N-methyl-2-pyrrolidone.
23 . A method for treating a psychiatric disease in a human having a TT genotype, a CC genotype, or a CT/TT genotype comprising administering a pharmaceutical composition comprising a therapeutically effective amount of (i) risperidone or a pharmaceutically acceptable salt thereof or (ii) paliperidone or a pharmaceutically acceptable salt thereof, to the human having the TT genotype, the CC genotype, or the CT/TT genotype to treat the psychiatric disease.
24 . The method of claim 23 , wherein the psychiatric disease is schizophrenia, bipolar disorder, or autism.
25 . The method of claim 24 , wherein the schizophrenia is acute schizophrenia.
26 . The method of any one of claims 23 - 25 , wherein the method comprises administering the pharmaceutical composition to the human by oral administration, by parenteral administration, or by surgical implantation.
27 . The method of any one of claims 23 - 25 , wherein the method comprises administering the pharmaceutical composition by intramuscular administration or by subcutaneous administration.
28 . The method of any one of claims 23 - 27 , wherein the pharmaceutical composition further comprises a poly(lactide-co-glycolide) copolymer.
29 . The method of claim 28 , wherein the poly(lactide-co-glycolide) copolymer is a 50:50 to 95:5 poly(lactide-co-glycolide) copolymer.
30 . The method of any one of claims 23 - 29 , wherein the pharmaceutical composition further comprises N-methyl-2-pyrrolidone.
31 . The method of any one of claims 28 - 30 , wherein the poly(lactide-co-glycolide) copolymer is in the form of microspheres.
32 . The method of any one of claims 23 - 27 , wherein the pharmaceutical composition comprises about 5 wt %/o to about 25 wt % risperidone base; about 25 wt % to about 50 wt % of a poly(lactide-co-glycolide)copolymer; and about 35 wt % to about 60 wt % N-methyl-2-pyrrolidone.
33 . The method of any one of claims 23 - 27 , wherein the pharmaceutical composition comprises about 15 wt % risperidone base; about 38 wt % of an 80:20 poly(lactide-co-glycolide)copolymer having a number average molecular weight from about 20,000 Daltons to about 30,000 Daltons; and about 47 wt % N-methyl-2-pyrrolidone.
34 . A method for treating a psychiatric disease in a human having a polymorphism in the MC4R gene, a polymorphism in the HTR2C gene, a polymorphism in the HTR2A gene, or a combination thereof, comprising administering to the human a therapeutically effective amount of an antipsychotic drug to treat the psychiatric disease.
35 . The method of claim 34 , wherein the psychiatric disease is schizophrenia.
36 . The method of claim 34 or 35 , wherein the human has a CC genotype, a TT genotype, or a CT/TT genotype.
37 . The method of any one of claims 34 - 36 , wherein the HTR2C gene has a single nucleotide polymorphism; the HTR2A gene has a single nucleotide polymorphism; and the MC4R gene has a single nucleotide polymorphism.
38 . The method of any one of claims 34 - 36 , wherein the HTR2C gene has an rs3813929 single nucleotide polymorphism; the HTR2A gene has an rs6313 single nucleotide polymorphism; and the MC4R gene has an rs17782313 single nucleotide polymorphism.
39 . The method of any one of claims 34 - 38 , wherein the antipsychotic drug is clozapine or a pharmaceutically acceptable salt thereof; loxapine or a pharmaceutically acceptable salt thereof; olanzapine or a pharmaceutically acceptable salt thereof: thioridazine or a pharmaceutically acceptable salt thereof, perphenazine or a pharmaceutically acceptable salt thereof; aripiprazole or a pharmaceutically acceptable salt thereof; iloperidone or a pharmaceutically acceptable salt thereof; ziprasidone or a pharmaceutically acceptable salt thereof; lurasidone or a pharmaceutically acceptable salt thereof; molindone or a pharmaceutically acceptable salt thereof; asenapine or a pharmaceutically acceptable salt thereof; mesoridazine or a pharmaceutically acceptable salt thereof; quetiapine or a pharmaceutically acceptable salt thereof; or trifluoperazine or a pharmaceutically acceptable salt thereof.