IP Library › Granted Patent US 10,618,978
Granted Patent B2
US 10,618,978 · App. 15/764,859 · Granted Apr 14, 2020

Binding molecules with modified J-chain

Inventors: Bruce A. Keyt (Hillsborough, CA); Leonard G. Presta (San Francisco, CA); Ramesh Baliga (Redwood City, CA)
Assignee: IGM Biosciences, Inc.
C07K16/468A61K39/39541A61K39/39558C07K16/28C07K16/2809C07K16/2881C07K16/2887A61K2039/505A61P27/00A61P35/02C07K2317/24C07K2317/31C07K2317/35C07K2317/52C07K2317/569C07K2317/622C07K2317/734C07K2317/90C07K2319/31C07K2319/735C07K2319/91
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Quick Facts
Patent No.
US 10,618,978
App. No.
15/764,859
Granted
Apr 14, 2020
Kind
B2
Abstract

The present invention concerns binding molecules that comprise an IgM, IgA, IgG/IgM or IgG/IgA antibody with a J-chain modified to include an AD-ME-modulating moiety, and their uses.

Claims (7)

1. An IgM antibody comprising the HCDR1 of SEQ ID NO: 65, the HCDR2 of SEQ ID NO: 66, the HCDR3 of SEQ ID NO: 67, the LCDR1 of SEQ ID NO: 69, the LCDR2 of SEQ ID NO: 70, the LCDR3 of SEQ ID NO: 71, and a modified J-chain, wherein the modified J-chain comprises the mature peptide formed from SEQ ID NO: 102, and wherein the IgM antibody binds CD20.

2. The IgM antibody of claim 1 , wherein the IgM antibody comprises the VH of SEQ ID NO: 64.

3. The IgM antibody of claim 1 , wherein the IgM antibody comprises the VL of SEQ ID NO: 68.

4. The IgM antibody of claim 1 , wherein the IgM antibody comprises the VH of SEQ ID NO: 64 and the VL of SEQ ID NO: 68.

5. The IgM antibody of claim 1 , wherein the IgM antibody comprises the heavy chain of SEQ ID NO: 82.

6. The IgM antibody of claim 1 , wherein the IgM antibody comprises the heavy chain of SEQ ID NO: 84.

7. The IgM antibody of claim 1 , wherein the IgM antibody comprises the heavy chain of SEQ ID NO: 82 and the light chain of SEQ ID NO: 84.

Assignments (2)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 10, 2018
From: IGM BIOSCIENCES A/S
To: IGM BIOSCIENCES, INC.
Reel/Frame 047044/0938 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 21, 2018
From: KEYT, BRUCE ALAN; PRESTA, LEONARD GEORGE; BALIGA, RAMESH
To: IGM BIOSCIENCES A/S
Reel/Frame 045865/0394 →
Continuity (2)
Provisional Application 62235518 · Sep 30, 2015
Related Publication 20180265596A1 · Sep 20, 2018
Cited By (2)
US 12,486,336 US 12,649,791