Medical device for fluid delivery having reduced dead space

1. A pharmaceutical syringe comprising:

a cylindrical bore having a proximal opening, a distal wall having an inner surface, an interior surface extending from said proximal opening to said distal wall, and a central axis, said inner surface having a first area and a second area distinct from said first area, said distal wall of said cylindrical bore defining an outlet, said outlet being spaced from said central axis toward said first area and away from said second area;

a hub extending from said distal wall, said hub defining a hub outlet and a fluid path extending from said outlet of said cylindrical bore to said hub outlet; and

a plunger seal positioned within and coaxial to said cylindrical bore, said plunger seal having a side surface configured to slidingly engage the interior surface of the cylindrical bore, a distal surface defining a center, the distal surface extending either perpendicular to said central axis or proximally as it extends radially from said center to said side surface;

wherein when said plunger seal is fitted within said cylindrical bore with said distal surface facing said inner surface of said distal wall of said cylindrical bore, said second area of said inner surface is axially closer to said distal surface of said plunger seal than said first area, in a direction parallel to said central axis of said cylindrical bore, allowing said second area to contact said distal surface of said plunger seal before said distal surface contacts said first area.

2. The pharmaceutical syringe of claim 1 , wherein a mean direction of said inner surface is tilted with respect to said central axis.

3. The pharmaceutical syringe of claim 2 , wherein said mean direction of said inner surface is tilted at an angle ranging from about 1 to about 5 degrees with respect to said central axis.

4. The pharmaceutical syringe of claim 1 , wherein said distal surface of said plunger seal comprises a convex shape with respect to the plunger seal.

5. The pharmaceutical syringe of claim 4 , wherein said inner surface comprises a concave shape with respect to the plunger seal.

6. The pharmaceutical syringe of claim 5 , wherein said inner surface comprises a conical shape, and wherein an opening angle of said inner surface is less sharp than an opening angle of said convex shape of said distal face of said plunger seal.

7. The pharmaceutical syringe of claim 1 , wherein said inner surface is not radially symmetrical.

8. The pharmaceutical syringe of claim 1 , wherein a mean direction of said first area of said inner surface is not parallel to a mean direction of said distal surface of said plunger seal, when said plunger seal being coaxial to said bore.

9. The pharmaceutical syringe of claim 1 , wherein a mean direction of said second area of said inner wall is parallel to a mean direction of said distal surface of said plunger seal, when said plunger seal being coaxial to said bore.

10. The pharmaceutical syringe of claim 1 , wherein a distance between a mean outer edge of the distal surface of the plunger seal and a mean outer edge of said second area being smaller than a distance between said mean outer edge of the distal surface of the plunger seal and a mean outer edge of said first area.

11. The pharmaceutical syringe of claim 1 , wherein a transition between a surface of said first area of said inner surface and a surface of said second area of said inner surface is continuous.

12. The pharmaceutical syringe of claim 1 , wherein said first area of said inner wall comprising said fluid outlet is located in proximity to an edge of said bore and said second area is located in proximity to the opposite edge of said bore.

13. The pharmaceutical syringe of claim 1 , further comprising a bent fluid path originating from said fluid outlet.

14. A method for reducing fluid dead space in a pharmaceutical syringe comprising a cylindrical bore with a proximal opening and a distal end including a fluid outlet spaced from a central axis of the cylindrical bore and an interior surface extending from said proximal opening to said distal end, and a hub extending from said distal end of said cylindrical bore, said hub defining a hub outlet and a fluid path extending from said outlet of said cylindrical bore to said hub outlet, and said cylindrical bore fitting a plunger seal having a distal surface, the plunger seal having a side surface configured to slidingly engage the interior surface of the cylindrical bore, the method comprising:

driving said plunger seal towards said distal end of said cylindrical bore, the distal surface of said plunger seal extending either perpendicular to said central axis or proximally as it extends radially from said central axis to said side surface;

contacting a portion of said distal surface of said plunger seal with a portion of an inner surface of a wall of said distal end of said cylindrical bore at a contact area distinct from an area comprising the fluid outlet; and

expanding a range of contact from said contact area towards the location of the fluid outlet while expelling fluid in a mean direction which is tilted with respect to a mean direction of said distal surface of said plunger seal,

wherein said contacting at said contact area comprises contacting said distal surface of said plunger seal before contacting said area comprising the fluid outlet.

15. The method of claim 14 , wherein said contacting comprises initially contacting at said contact area being a peripheral edge of said inner surface, said peripheral edge being distinct to said area comprising said fluid outlet.

16. The method of claim 14 , wherein said expanding comprises expanding said range of contact from said peripheral edge, through a center portion of said inner wall and onto said area comprising said fluid outlet.

17. The method of claim 14 , wherein said expanding said range of contact is conducted by elastically deforming said plunger seal.

18. The method of claim 14 , wherein said expanding said range of contact results in driving fluid away from said contact location towards said location of said fluid outlet.

19. The method of claim 14 , further comprising ending said driving of said plunger seal at a force ranging between about 5 N and about 25 N.

20. The method of claim 19 , wherein following said ending, a volume of a fluid dead space between said plunger seal and said inner wall ranges between about 0.01 ml and about 0.5 ml.