Combination therapy for treating malignancies
Provided are methods and compositions for treating AML in patients carrying an IDH2 mutation using a combination of an inhibitor of a mutant IDH2 enzyme and an AML induction and consolidation therapy.
1. A method of treating a newly diagnosed acute myeloid leukemia (AML), comprising administering to a subject a therapeutically effective amount of a mutant IDH2 inhibitor and a combination of Cytarabine and Daunorubicin as an induction therapy, further comprising administering a therapeutically effective amount of a mutant IDH2 inhibitor in combination of Mitoxantrone and Etoposide as a consolidation therapy, wherein the mutant IDH2 inhibitor is 2-methyl-1-[(4-[6-(trifluoromethyl)pyridin-2-yl]-6-{[2-(trifluoromethyl)pyridin-4-yl]amino}-1,3,5-triazin-2-yl)amino]propan-2-ol having the following formula:
or a pharmaceutically acceptable salt, solvate, tautomer, stereoisomer, isotopologue, or a polymorph thereof (COMPOUND 1), and wherein the AML is characterized by the presence of a mutant allele of IDH2.
2. The method of claim 1 , wherein between about 1 mg/m 2 /day and about 25 mg/m 2 /day of Mitoxantrone is administered to the subject.
3. The method of claim 2 , wherein between about 5 mg/m 2 /day and about 20 mg/m 2 /day of Mitoxantrone is administered to the subject.
4. The method of claim 3 , wherein about 10 mg/m 2 /day of Mitoxantrone is administered to the subject.
5. The method of claim 1 , wherein between about 50 mg/m 2 /day and about 500 mg/m 2 /day of Etoposide is administered to the subject.
6. The method of claim 5 , wherein between about 75 mg/m 2 /day and about 250 mg/m 2 /day of Etoposide is administered to the subject.
7. The method of claim 6 , wherein about 100 mg/m 2 /day of Etoposide is administered to the subject.
8. The method of claim 1 , wherein between about 100 mg/m 2 /day and about 500 mg/m 2 /day of Cytarabine is administered to the subject as an induction therapy.
9. The method of claim 1 , wherein between about 10 mg/m 2 /day and about 300 mg/m 2 /day of Daunorubicin is administered to the subject.
10. A method of claim 1 , wherein between about 50 mg/m 2 /day and about 1000 mg/m 2 /day of COMPOUND 1 is administered to the subject.
11. The method of claim 1 , wherein between about 150 mg/m 2 /day and about 300 mg/m 2 /day of Cytarabine is administered to the subject as an induction therapy.
12. The method of claim 1 , wherein about 200 mg/m 2 /day of Cytarabine is administered to the subject as an induction therapy.
13. The method of claim 1 , wherein between about 1 g/m 2 /day and about 10 g/m 2 /day of Cytarabine is administered to the subject as a consolidation therapy.
14. The method of claim 1 , wherein between about 1 g/m 2 /day and about 5 g/m 2 /day of Cytarabine is administered to the subject as a consolidation therapy.
15. The method of claim 1 , wherein 1 g/m 2 /day, 1.5 g/m 2 /day, 2 g/m 2 /day or 3 g/m 2 /day of Cytarabine is administered to the subject as a consolidation therapy.
16. The method of claim 1 , wherein between about 30 mg/m 2 /day and about 150 mg/m 2 /day of Daunorubicin is administered to the subject.
17. The method of claim 1 , wherein about 60 mg/m 2 /day of Daunorubicin is administered to the subject.
18. The method of claim 1 , wherein between about 150 mg/m 2 /day and about 300 mg/m 2 /day of COMPOUND 1 is administered to the subject.
19. The method of claim 1 , wherein about 200 mg/m 2 /day of COMPOUND 1 is administered to the subject.
20. The method of claim 1 , wherein between about 50 mg/day and 1000 mg/day of COMPOUND 1 is administered to the subject.
21. The method of claim 1 , wherein between about 100 mg/day and 500 mg/day of COMPOUND 1 is administered to the subject.
22. The method of claim 1 , wherein is about 100 mg/day of COMPOUND 1 is administered to the subject.