Polypeptides against IL-23
The present invention relates to amino acid sequences that are directed against Interleukin-23 (IL-23). The amino acid sequences of the present invention comprise two NANOBODIES® against IL-23 and one NANOBODY® against serum albumin, linked by two linkers (9GS linkers). In particular, the invention relates to the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 3 (listed in Table 1 and FIG. 1 ) (also referred to herein as “anti-IL 23 polypeptides of the invention”).
1. Polypeptide comprising an amino acid sequence that is chosen from the amino acid sequences of SEQ ID NO: 2 and SEQ ID NO: 3.
2. Polypeptide comprising the amino acid sequence of SEQ ID NO: 2.
3. Polypeptide comprising the amino acid sequence of SEQ ID NO: 3.
4. Composition comprising a polypeptide according to claim 1 .
5. A method for treating colitis, Crohn's disease, inflammatory bowel disease, psoriasis, or rheumatoid arthritis, comprising administering to a subject in need of such treatment a therapeutically active amount of a polypeptide according to claim 1 .
6. A method for treating colitis, Crohn's disease, inflammatory bowel disease, psoriasis, or rheumatoid arthritis, comprising administering to a subject in need of such treatment a therapeutically active amount of a polypeptide according to claim 2 .
7. A method for treating colitis, Crohn's disease, inflammatory bowel disease, psoriasis, or rheumatoid arthritis, comprising administering to a subject in need of such treatment a therapeutically active amount of a polypeptide according to claim 3 .
8. A method for treating colitis, Crohn's disease, inflammatory bowel disease, psoriasis, or rheumatoid arthritis, comprising administering to a subject in need of such treatment a therapeutically active amount of a composition according to claim 4 .