Use of dermcidin in sterile inflammatory conditions
View Patent ↗A method of treating a sterile inflammatory condition in a subject using an isolated dermcidin peptide or an active fragment thereof of or an active analog thereof is provided. Also provided is a method of inhibiting organ transplantation-associated is chemia/reperfusion and/or organ transplantation-associated inflammation.
1. A method of inhibiting sterile organ transplantation-associated ischemia/reperfusion and/or organ transplantation-associated inflammation in a recipient subject comprising storing and/or rinsing the organ to be transplanted in a solution comprising an amount of an isolated-dermcidin peptide having SEQ ID NO:1 wherein the cysteine at position 15 (“Cysteine 34”) is optionally substituted with a serine and wherein SEQ ID NO:1 optionally has an N-terminal histidine tag, effective to inhibit sterile organ transplantation-associated ischemia/reperfusion and/or organ transplantation-associated inflammation in a recipient subject.
2. The method of claim 1 , wherein the organ is a kidney, liver, heart, or lung.