Stabilizer and stabilization method
The invention relates to a stabilizer for L-012 or a salt thereof, a stabilization method for L-012 or a salt thereof, coexisting with the stabilizer and L-012 or a salt thereof, and the like. The stabilizer is represented by Formula [1]: wherein p pieces of M1 each independently represent a hydrogen atom or an alkali metal atom, q pieces of R1 each independently represent a hydroxy group or a sulfonic acid group, m represents 0 or 1, p represents an integer of 1 to 3, q represents an integer of 0 to 4, Y represents a nitrogen atom or a CH group (a methine group), and Z represents an aryl group having a specific structure or a pyrazolyl group having a specific structure.
1. A stabilization method for 8-amino-5-chloro-7-phenylpyrido[3,4-d]pyridazine-1,4(2H,3H)-dione or a salt thereof, wherein a compound selected from 4-hydroxy-5-(salicylidenamino)-2,7-naphthalenedisulfonic acid or a salt thereof, 7-hydroxy-8-(4-sulfo-1-naphthylazo)-1,3-naphthalenedisulfonic acid or a salt thereof, 2-(4-sulfophenylazo)-1,8-dihydroxy-3,6-naphthalenedisulfonic acid or a salt thereof, 3-[4-(phenylamino)phenylazo]benzenesulfonic acid or a salt thereof, and 3-hydroxy-4-[4-(4-sulfophenylazo)-2-sulfophenylazo]-2,7-naphthalenedisulfonic acid or a salt thereof is coexisted with 8-amino-5-chloro-7-phenylpyrido[3,4-d]pyridazine-1,4(2H,3H)-dione or a salt thereof.
2. The stabilization method according to claim 1 , wherein the compound is 4-hydroxy-5-(salicylidenamino)-2,7-naphthalenedisulfonic acid or a salt thereof.
3. The stabilization method according to claim 1 , wherein the compound is 7-hydroxy-8-(4-sulfo-1-naphthylazo)-1,3-naphthalenedisulfonic acid or a salt thereof.
4. The stabilization method according to claim 1 , wherein the compound is 2-(4-sulfophenylazo)-1,8-dihydroxy-3,6-naphthalenedisulfonic acid or a salt thereof.
5. The stabilization method according to claim 1 , wherein the compound is 3-[4-(phenylamino)phenylazo]benzenesulfonic acid or a salt thereof.
6. The stabilization method according to claim 1 , wherein the compound is 3-hydroxy-4-[4-(4-(4-sulfophenylazo)-2-sulfophenylazo]-2,7-naphthalenedisulfonic acid or a salt thereof.
7. A composition comprising 8-amino-5-chloro-7-phenylpyrido[3,4-d]pyridazine-1,4(2H,3H)-dione or a salt thereof, and a compound selected from 4-hydroxy-5-(salicylidenamino)-2,7-naphthalenedisulfonic acid or a salt thereof, 7-hydroxy-8-(4-sulfo-1-naphthylazo)-1,3-naphthalenedisulfonic acid or a salt thereof, 2-(4-sulfophenylazo)-1,8-dihydroxy-3,6-naphthalenedisulfonic acid or a salt thereof, 3-[4-(phenylamino)phenylazo]benzenesulfonic acid or a salt thereof, and 3-hydroxy-4-[4-(4-sulfophenylazo)-2-sulfophenylazo]-2,7-naphthalenedisulfonic acid or a salt thereof.
8. The composition according to claim 7 , wherein the compound is 4-hydroxy-5-(salicylidenamino)-2,7-naphthalenedisulfonic acid or a salt thereof.
9. The composition according to claim 7 , wherein the compound is 7-hydroxy-8-(4-sulfo-1-naphthylazo)-1,3-naphthalenedisulfonic acid or a salt thereof.
10. The composition according to claim 7 , wherein the compound is 2-(4-sulfophenylazo)-1,8-dihydroxy-3,6-naphthalenedisulfonic acid or a salt thereof.
11. The composition according to claim 7 , wherein the compound is 3-[4-(phenylamino)phenylazo]benzenesulfonic acid or a salt thereof.
12. The composition according to claim 7 , wherein the compound is 3-hydroxy-4-[4-(4-sulfophenylazo)-2-sulfophenylazo]-2,7-naphthalenedisulfonic acid or a salt thereof.
13. A kit for measuring a luminescence, comprising 8-amino-5-chloro-7-phenylpyrido[3,4-d]pyridazine-1,3(2H,3H)-dione or a salt thereof, and a compound selected from 4-hydroxy-5-(salicylidenamino)-2,7-naphthalenedisulfonic acid or a salt thereof, 7-hydroxy-8-(4-sulfo-1-naphthyl azo)-1,3-naphthalenedisulfonic acid or a salt thereof, 2-(4-sulfophenylazo)-1,8-dihydroxy-3,6-naphthalenedisulfonic acid or a salt thereof, 3-[4-(phenylamino)phenylazo]benzenesulfonic acid or a salt thereof, and 3-hydroxy-4-[4-(4-sulfophenylazo)-2-sulfophenylazo]-2,7-naphthalenedisulfonic acid or a salt thereof.
14. The kit for measuring a luminescence according to claim 13 , wherein the compound is 4-hydroxy-5-(salicylidenamino)-2,7-naphthalenedisulfonic acid or a salt thereof.
15. The kit for measuring a luminescence according to claim 13 , wherein the compound is 7-hydroxy-8-(4-sulfo-1-naphthylazo)-1,3-naphthalenedisulfonic acid or a salt thereof.
16. The kit for measuring a luminescence according to claim 13 , wherein the compound is 2-(4-sulfophenylazo)-1,8-dihydroxy-3,6-naphthalenedisulfonic acid or a salt thereof.
17. The kit for measuring a luminescence according to claim 13 , wherein the compound is 3-[4-(phenylamino)phenylazo]benzenesulfonic acid or a salt thereof.
18. The kit for measuring a luminescence according to claim 13 , wherein the compound is 3-hydroxy-4-[4-(4-sulfophenylazo)-2-sulfophenylazo]-2,7-naphthalenedisulfonic acid or a salt thereof.