Devices for creating an epidermal graft sheet

1. A device for obtaining a skin graft, the device comprising:

a base having an opening;

a skin depression array sized and shaped for positioning within the opening of the base and comprising a plurality of interconnected protrusions, wherein the protrusions are configured to depress portions of skin at a donor site during blister formation and thereby shield the depressed portions of skin from blistering; and

a blade assembly coupled to the base and configured to cut a raised skin blister within the opening while sparing the shielded portions of skin.

2. The device of claim 1 , wherein the blade assembly comprises a handle, at least one sliding arm, and a blade.

3. The device of claim 1 , further comprising a hollow body, the hollow body having a distal end configured for placement at the donor site, wherein the hollow body is further configured to raise a skin blister at the donor site.

4. The device of claim 3 , wherein the hollow body further comprises a harvester head component and a harvester base component adapted to be joined together to define an inner chamber therebetween.

5. The device of claim 4 , further comprising a coupling port configured to place the inner chamber of the hollow body in communication with a source of negative pressure.

6. The device of claim 5 , further comprising a heating element disposed within the inner chamber of the hollow body.

7. The device of claim 6 , wherein the heating element comprises a heat source configured to conduct heat.

8. The device of claim 6 , wherein the heating element is integrated with the skin depression array.

9. The device of claim 6 , wherein the source of negative pressure and the heating element are configured to induce formation of at least one skin blister at the donor site.

10. The device of claim 9 , wherein the at least one skin blister is a single, continuous skin blister.

11. The device of claim 1 , wherein the skin depression array further comprises a support frame, wherein the support frame comprises a plurality of apertures and connects at least a portion of the plurality of interconnected protrusions.

12. The device of claim 1 , wherein the protrusions have a generally circular cross-section.

13. The device of claim 12 , wherein the array comprises one of about 2 to about 500 protrusions or about 10 to about 200 protrusions.

14. The device of claim 1 , wherein the protrusions are substantially uniform in size.

15. The device of claim 1 , wherein the array further comprises one or more separators, wherein each of the one or more separators are configured to depress one or more areas of skin at the donor site such that more than one blister is raised at the donor site.

16. The device of claim 1 , wherein the raised skin blister is about 80% to about 95% of skin at the donor site.

17. A device for obtaining a skin graft, the device comprising:

a hollow body configured to raise a blister sheet at the donor skin site, the hollow body comprising:

a distal end configured to be placed at a donor skin site; and

an opening defining a skin graft harvest area; and

at least one array sized for removable positioning within the opening of the hollow body, the at least one array comprising a plurality of protrusions, wherein the protrusions are configured to contact portions of skin at a donor site and shield the contacted portions of skin from blistering; and

a blade assembly configured to cut the raised blister sheet while sparing the portions of skin in contact with the protrusions.

18. The device of claim 17 , wherein the array is removably replaceable with a different array.

19. The device of claim 18 , wherein the different array comprises protrusions having at least one of a different shape, different diameter, different depth, or different spacing.

20. The device of claim 17 , wherein protrusions are symmetrically sized and shaped.

21. The device of claim 17 , wherein the protrusions are interconnected.