Thylakoid extract composition and formulation for the treatment of inflammatory bowel disease
There is provided the use of a functional thylakoid extract, particularly in admixture with a physiologically acceptable carrier, in pharmaceutical application, in the treatment of inflammatory bowel disease, and method for the treatment thereof. The inflammatory bowel disease may comprise several diseases associated with inflammation of the small intestine, large intestine (colon), rectum or anus (anal sphincter), and may be particularly selected from ulcerative colitis and Crohn's disease.
1. A method for treating inflammatory bowel disease (IBD) in a human subject in need thereof, comprising intra-rectally administering to said subject for at least 21 days a daily dose of 250 mg of an active thylakoid extract comprising purified functional photosynthetic pigments in their thylakoid membrane environment wherein said administering decreases a baseline level of serum C-reactive protein (C-RP) or serum high-sensitivity C-reactive protein (hsCRP) in said subject by about 78% after 21 days of administration, wherein said baseline level of CRP or hsCRP is measured prior to said administration.
2. The method of claim 1 , wherein said extract is stabilized in a medium comprising less than 10% of electron donor.
3. The method of claim 2 , wherein said medium comprises less than 10% of water.
4. The method of claim 1 , wherein said thylakoid extract is in admixture with a physiologically acceptable carrier suitable for oral administration.
5. The method of claim 4 , wherein said thylakoid extract is in admixture with a physiologically acceptable carrier suitable for intra-rectal administration.
6. The method of claim 5 , wherein said extract is comprised in an enema solution.
7. The method of claim 1 , wherein said IBD is selected from: ulcerative colitis and Crohn's disease.
8. The method of claim 7 , wherein said IBD is ulcerative colitis.
9. The method of claim 1 , wherein the extract is present in an amount achieving about 0.00005 to 500 mg per kg of subject's body weight.
10. The method of claim 5 , wherein said extract is comprised in a suppository.