IP Library Granted Patent US 11,118,154
Granted Patent B2
US 11,118,154 · App. 15/773,651 · Granted Sep 14, 2021

Networked incubator operation

Inventor: Howard Cannon (Boston, MA)
Assignee: Thrive Bioscience, Inc.
C12M41/48C12M1/005C12M41/14G16B40/00G16B50/00
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Quick Facts
Patent No.
US 11,118,154
App. No.
15/773,651
Granted
Sep 14, 2021
Kind
B2
Abstract

Aspects of the present invention relate to a networked cell culture incubator and to methods for operating such an incubator. In one aspect, the cell culture incubator includes a network interface for communicating with a source of parameter data utilized successfully by other incubators. The incubator receives appropriate parameter data and conducts the incubation process as prescribed by the parameter data so as to provide an improved environment for cell culture growth. The incubator may share its own parameter data with the data source for use by other incubators. The incubator and data source may share other forms of data as well.

Claims (26)

1. A non-transitory computer-readable medium having instructions stored thereon for performing a method of facilitating networked incubator operation, the instructions operable on one or more processors to perform operations comprising:

controlling a first networked incubator system to image cell cultures therein, stitch the images together, and analyze the images to provide image analysis data;

receiving, from the first networked incubator system, data that comprises incubator operating parameters for operating a networked incubator system, image data and image analysis data;

storing the received parameter data, the image data and the image analysis data in a database;

receiving a query for incubator operating parameters from a second networked incubator system; and

transmitting, from the database in response to the received query from the second networked incubator system, data that corresponds to the data received from the first networked incubator system and is arranged to control operation of the second networked incubator system.

2. The computer readable medium of claim 1 , further having instructions stored thereon for transmitting data from the first networked incubator system to one or more servers comprising at least one of a laboratory information management system and an electronic lab notebook to provide a permanent record of the operating parameters.

3. The computer readable medium of claim 2 , wherein the data transmitted to the servers comprise an image, information derived from an image, a step in a process for incubator operation, temperature data, cell type data, time data, cell growth data, and growth medium data.

4. The computer readable medium of claim 1 , further having instructions for anonymizing the received parameter data transmitted to the second networked incubator so that the first networked incubator system cannot be identified from the transmitted parameter data.

5. The computer readable medium of claim 1 , further having instructions for computing values derived from the received parameter data by deep learning.

6. The computer readable medium of claim 1 , wherein the image analysis data detects discrepancies between stem cells during cell development to thereby change incubator system operating parameters.

7. The computer readable medium of claim 1 , wherein the query received from the second networked incubator system comprises at least one of: an image, information derived from an image, a step in a process for incubator operation, temperature data, cell type data, time data, cell growth data, and growth medium data.

8. The computer readable medium of claim 1 , wherein the first networked incubator system and the second networked incubator system are the same networked incubator system.

9. A method of facilitating networked incubator operation, the method comprising:

controlling a first networked incubator system to image cell cultures therein, stitch the images together, and analyze the images to provide image analysis data;

receiving, from theft first networked incubator system, data comprising incubator operating parameters for operating a networked incubator system, image data and image analysis data;

storing the received parameter data, the image data and the image analysis data in a database;

receiving, from a second networked incubator system, a query for incubator operating parameters; and

transmitting data from the database in response to the received query, the data corresponding to the data received from the first networked incubator system and arranged to control operation of the second networked incubator system.

10. The method of claim 9 , further having instructions stored thereon for transmitting data from the first networked incubator system to one or more servers comprising at least one of a laboratory information management system and an electronic lab notebook to provide a permanent record of the operating parameters.

11. The method of claim 9 , wherein the data transmitted to the servers comprise an image, information derived from an image, a step in a process for incubator operation, temperature data, cell type data, time data, cell growth data, and growth medium data.

12. The method of claim 9 , further comprising anonymizing the parameter data transmitted to the second networked incubator so that the first networked incubator system cannot be identified from the transmitted parameter data.

13. The method of claim 9 , further comprising computing values derived from the received parameter data by deep learning.

14. The method of claim 13 , wherein the image analysis data detects discrepancies between stem cells during cell development to thereby change incubator system operating parameters.

15. The method of claim 9 , wherein the query received from the second networked incubator system comprises at least one of: an image, information derived from an image, a step in a process for incubator operation, temperature data, cell type data, time data, cell growth data, and growth medium data.

16. The method of claim 9 , wherein the first networked incubator system and the second networked incubator system are the same networked incubator system.

Assignments (3)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 17, 2021
From: CANNON, HOWARD
To: THRIVE BIOSCIENCE, INC.
Reel/Frame 056265/0093 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 22, 2020
From: CANNON, HOWARD
To: THRIVE BIOSCIENCE, INC.
Reel/Frame 054135/0395 →
SECURITY INTEREST Recorded Mar 12, 2020
From: THRIVE BIOSCIENCE, INC.
To: EGENDORF, ANDREW
Reel/Frame 052093/0256 →
Continuity (2)
Provisional Application 62250986 · Nov 4, 2015
Related Publication 20180320127A1 · Nov 8, 2018