4-((6-(2-(2,4-DIFLUOROPHENYL)-1,1-DIFLUORO-2-HYDROXY-3-(1H-1,2,4-TRIAZOL-1-YL)PROPYL)PYRIDIN-3-YL)OXY)BENZONITRILE AND PROCESSES OF PREPARATION
Provided herein is a process for the preparation of 4-((6-(2-(2,4-difluorophenyl)-1,1-difiuoro-2-hydroxy-3-(1H-1,2,4-triazol-1-yl)propyl)pyridin-3-yl)oxy)benzonitrile.
1 . A method of making a compound of Formula I
comprising the step of contacting a compound of Formula II
with a trialkylsulfoxonium halide, a base, and 1H-1,2,4-triazole.
2 . The method of claim 1 , wherein the trialkylsulfoxonium halide is one of trimethylsulfoxonium iodide, trimethylsulfoxonium bromide and trimethylsulfoxonium chloride.
3 . The method of claim 1 , wherein the base may be selected from the group including metal carbonates, metal alkoxides and metal bicarbonates.
4 . The method of claim 1 , wherein the base may be one of potassium carbonate and sodium tert-butoxide.
5 . The method of claim 1 further comprising a solvent selected from the group including dimethylsulfoxide (DMSO), dimethylformamide (DMF), sulfolane, tetrahydrofuran (THF), water, N-methyl-2-pyrrolidone (NMP), and mixtures thereof.
6 . The method of claim 1 further comprising a solvent selected from the group including THF, water, DMSO, and mixtures thereof.
7 . The method of claim 1 wherein the contacting is carried out from about −20° C. to about 100° C.
8 . The method of claim 1 wherein the contacting is carried out from about 20° C. to about 80° C.