Use of ivermectin and brimonidine in the treatment and/or prevention of moderate to severe rosacea
The present invention relates to a combination of ivermectin and brimonidine for use in the treatment and/or the prevention of moderate to severe rosacea, preferably by topical administration of a 1% ivermectin cream and 0.33% brimonidine gel.
1. A method of treating rosacea in a subject in need thereof, comprising topically administering, daily for at least 12 weeks:
(a) a composition comprising ivermectin in the form of a cream; and
(b) a composition comprising brimonidine or salts thereof in the form of a gel,
wherein:
ivermectin is present in an amount of between 0.75 and 1.5 percent by weight, relative to the total weight of the composition comprising ivermectin;
brimonidine or salts thereof are present in an amount of between 0.05 and 1 percent by weight, relative to the total weight of the composition comprising brimonidine; and
the ivermectin and brimonidine are present separately within distinct compositions.
2. The method of claim 1 , wherein ivermectin is present in an amount of 0.75, 1, or 1.5 percent by weight, relative to the total weight of the composition comprising ivermectin.
3. The method of claim 1 , wherein brimonidine or salts thereof are present in an amount of 0.33 percent by weight, relative to the total weight of the composition comprising brimonidine.
4. The method of claim 1 , wherein the composition comprising ivermectin is administered in the morning.
5. The method of claim 1 , wherein the composition comprising brimonidine is administered in the evening.
6. The method of claim 1 , wherein the composition comprising ivermectin is administered in the morning and the composition comprising brimonidine is administered in the evening.
7. The method of claim 1 , wherein the ivermectin is present at a concentration 1 percent by weight, relative to the total weight of the composition comprising ivermectin.