AN ENZYME DELIVERY SYSTEM AND METHODS RELATING THERETO
The present disclosure is directed to an enzyme delivery system having a plurality of solution spun fibers. The solution spun fibers made from a water soluble polymeric resin and an enzyme. The enzyme is encapsulated in the solution spun fibers and is present in an amount from 0.1 to 40 wt % based on total weight of the solution spun fibers. The percent of active enzyme after encapsulation is from 50 to 100%.
1 . An enzyme delivery system comprising:
a plurality of solution spun fibers comprising:
a) a water soluble polymeric resin; and
b) an enzyme;
wherein the enzyme is encapsulated in the solution spun fibers and is present in an amount from 0.1 to 40 wt % based on total weight of the solution spun fibers;
wherein percent of active enzyme after encapsulation is from 50 to 100%; and
wherein at least a portion of the solution spun fibers have a fiber diameter of 25 microns or less.
2 . The enzyme delivery system in accordance with claim 1 , wherein the water soluble polymeric resin is methylcellulose, hydroxypropyl methylcellulose, guar gum, alginate, polyvinyl pyrrolidone, polyethylene oxide, polyvinyl alcohol, pullulan, polyaspartic acid, polyacrylic acid, copolymers thereof or mixtures thereof.
3 . The enzyme delivery system in accordance with claim 1 , wherein the water soluble polymeric resin is polyvinyl pyrrolidone, polyvinyl alcohol, pullulan or mixtures thereof.
4 . The enzyme delivery system in accordance with claim 1 , wherein the solution spun fibers have a crystallinity from 20 to 54%
5 . The enzyme delivery system in accordance with claim 1 , wherein the solution spun fibers have a crystallinity less than 35%.
6 . The enzyme delivery system in accordance with claim 1 , wherein the enzyme is provided in a composition that is substantially free of cells or cell debris.
7 . The enzyme delivery system in accordance with claim 1 , wherein the enzyme is selected from: peroxidases, gluco-amylases, xylanases, hemicelluloses, cellulases, lipolytic enzymes, metallolipolytic enzymes, pectate lyases, metalloproteinase, amadoriase, arabinofuranosidases, phytases, isomerases, lipases, phospholipases, esterases, cutinases, pectinases, keratanases, reductases, oxidases, phenoloxidases, lipoxygenases, ligninases, pullulanases, tannases, pentosanases, malanases, beta-glucanases, arabinosidases, hyaluronidase, chondroitinase, dextranase, transferase, laccase, mannanase, xyloglucanases, or mixtures thereof.
8 . The enzyme delivery system in accordance with claim 1 , wherein the enzyme is selected from perhydrolase, protease, amylase or mixtures thereof.
9 . The enzyme delivery system in accordance with claim 1 , wherein the solution spun fibers form a woven web, fragmented woven web, a non-woven web, a fragmented non-woven web or individual fibers.
10 . An aqueous composition comprising the enzyme delivery system in accordance with claim 1 , wherein the aqueous composition comprises 70 wt % or less of water based on total weight of the aqueous composition.
11 . The enzyme delivery system in accordance with claim 1 , used in a liquid detergent composition comprising 70 wt % or less of water based on total weight of the liquid detergent composition and wherein the enzyme is any enzyme suitable for use in detergent compositions.
12 . The enzyme delivery system in accordance with claim 10 wherein the enzyme is protease, amylase or mixtures thereof.
13 . The enzyme delivery system in accordance with claim 1 , wherein enzyme leakage is 21% or less after 200 days when the enzyme delivery system is suspended in an aqueous composition comprising 35 wt % water or less based on the total weight of the aqueous composition and wherein the aqueous composition is at a temperature from 20 to 30 degrees C.
14 . The enzyme delivery system in accordance with claim 13 , wherein the enzyme leakage is 10% or less after 200 days, when the enzyme delivery system is suspended in an aqueous composition comprising 35 wt % water or less based on total weight of the aqueous composition and wherein the aqueous composition is at a temperature from 20 to 30 degrees C.
15 . The enzyme delivery system in accordance with claim 14 , wherein the enzyme leakage is 4% or less after 200 days when the enzyme delivery system is suspended in an aqueous composition comprising 35 wt % water or less based on total weight of the aqueous composition and wherein the aqueous composition is at a temperature from 20 to 30 degrees C.
16 . The enzyme delivery system in accordance with claim 1 , wherein enzyme leakage is 21% or less after 14 days when the enzyme delivery system is suspended in an aqueous composition comprising 35 wt % water or less based on the total weight of the aqueous composition and wherein the aqueous composition is at a temperature from 20 to 30 degrees C.
17 . The enzyme delivery system in accordance with claim 1 , wherein the solution spun fibers have a solubility of 7.7 mg/mL or less in water at a temperature from 30 to 0 degrees C.
18 . The enzyme delivery system in accordance with claim 1 , wherein enzyme leakage is less than 32% after 30 minutes when the enzyme delivery system is suspended in an aqueous composition comprising 70 wt % water or less based on total weight of the aqueous composition and wherein the aqueous composition is at a temperature from 20 to 30 degrees C.
19 . The enzyme delivery system in accordance with claim 1 , used in a laundry prespotting composition comprising 70 wt % or less of water based on total weight of the laundry prespotting composition.
20 . The enzyme delivery system in accordance with claim 1 , further comprising a substrate, mediator, or cofactor for the enzyme.
21 . The enzyme delivery system in accordance with claim 1 wherein at least 90 wt % of the encapsulated enzyme is released into an aqueous composition at a temperature ranging from 0 to 30 degrees C. in a time that is less than 15 minutes after the aqueous composition is diluted with water to contain greater than 70 weight percent water.