Compression blow formed HDPE containers and methods of making the same

1. A method of making an article, comprising:

compression blow forming an HDPE resin characterized by:

a halftime of crystallization of less than 2 minutes when measured at 124° C.,

a density of at least about 0.955,

a die swell of less than about 1.5,

wherein the article is a pharmaceutical bottle having a higher degree of crystallinity than a pharmaceutical bottle formed from an otherwise comparable resin having a higher halftime of crystallization.

2. The method of claim 1 , wherein the resin is further characterized by:

a melt flow index of less than about 1.8 when measured according to ASTM D1238.

3. The method of claim 1 , wherein the halftime of crystallization is less than 1 minute when measured at 124° C.

4. The method of claim 1 , wherein the ratio of a height of the pharmaceutical bottle to a diameter of the pharmaceutical bottle is 4:1 or less.

5. The method of claim 1 , wherein the article has a moisture vapor transmission rate of less than about 2 mg/day in a 150 cc bottle having an average thickness of 0.77 mm measured at 50° C. at 50% relative humidity, according to USP <661>.

6. The method of claim 1 , wherein the resin comprises a mixture of two or more resins.

7. The method of claim 6 , wherein the mixture of two or more resins comprises:

a first resin present in the mixture in an amount of from about 90 wt. % to about 98 wt. % of the mixture; and

a second resin present in the mixture in an amount of from about 2 wt. % to about 10 wt. % of the mixture,

wherein the first resin has a melt flow index of from about 1 to about 2 and the second resin has a melt flow index of from about 0.35 to about 0.80.

8. The method of claim 1 , wherein the resin comprises a nucleating agent in an amount of less than about 5 wt. %.

9. The method of claim 1 , wherein the resin comprises a delustrant.

10. The method of claim 1 , wherein the pharmaceutical bottle has a volume of 60 cubic centimeters or 150 cubic centimeters.