Aseptic cartridge and dispenser arrangement
A cartridge for use with a beneficial agent delivery device having a fillable reservoir. The cartridge includes a reconstitution, unit dose package having first and second compartments, and a fitment. The first compartment contains at least a first constintuent of the beneficial agent. The second compartment contains at least a second constituent of the beneficial agent. The fitment is disposed on the package for interfacing the package to the fillable reservoir.
1. A cartridge for use with a beneficial agent delivery device, said delivery device having a fillable reservoir, said cartridge comprising:
a reconstitution unit dose package, comprising:
a first compartment containing at least a first constituent of the beneficial agent;
at least a second compartment containing at least a second constituent of the beneficial agent; and
a fitment disposed on said package and configured to establish a fluid interface between said package and the fillable reservoir; and
a coupler separate from the reconstitution unit dose package, the coupler configured to support at least part of the reconstitution unit dose package and provide a cap for receiving at least a delivery portion of the delivery device;
wherein at least one of the first compartment and the second compartment comprises a flexible wall having a pre-formed structure; and
wherein the coupler provides an aseptic engagement between the package and the delivery device.
2. The cartridge of claim 1 wherein the delivery portion of the delivery device comprises one of a needle, a connector, or a nozzle.
3. The cartridge of claim 1 wherein said first compartment is segregated from said second compartment by a rupturable barrier.
4. The cartridge of claim 1 further comprising a foil layer peelable off at least one of the first compartment and the second compartment.
5. The cartridge of claim 1 further comprising a fluid passageway between said first compartment and said second compartment.
6. The cartridge of claim 5 further comprising a static mixer disposed in said fluid passageway.
7. The cartridge of claim 1 further comprising a fluid passageway between said package and the delivery device, and a static mixer disposed in the fluid passageway.
8. The cartridge of claim 1 further comprising a filling compartment in fluid communication with said first compartment via a fluid filling passageway.
9. The cartridge of claim 8 wherein said fluid passageway is sealable to prevent fluid communication between the filling compartment and the first compartment.
10. The cartridge of claim 8 wherein said filling passageway is configured to direct fluid along a first wall of said first compartment to prevent jetting.
11. The cartridge of claim 8 further comprising a gas evacuation chamber in communication with said first compartment via a fluid evacuation passageway, said fluid evacuation passageway having a gas-permeable, liquid-impermeable seal disposed therein.
12. The cartridge of claim 1 , wherein at least a portion of said first compartment or said second compartment comprises a tubular construction.
13. The cartridge of 15 wherein the filling compartment is configured to form a fluid tight communication with a filling system.
14. The cartridge of claim 1 , wherein a periphery of said first compartment is sealed to said reinforced backing and side walls of said first compartment extend in a direction generally perpendicular to said reinforced backing.
15. The cartridge of claim 1 wherein:
said first compartment comprises a flexible wall having a pre-formed structure; and
said first compartment is moveable between a pre-formed state in which said pre-formed structure defines a fillable cavity configured to receive the beneficial agent and a second deformed state in which the volume is substantially depleted.