Haptens of aripiprazole
The invention relates to compounds of Formula I, wherein R 1 , R 2 , and R 3 are defined in the specification, useful for the synthesis of novel conjugates and immunogens derived from aripiprazole. The invention also relates to conjugates of an aripiprazole hapten and a protein.
1. A compound of Formula I:
wherein:
R 1 is H,
R 2 is H or
R 3 is H; provided that either R 1 or R 2 must be H, and further provided that both R 1 and R 2 may not be H simultaneously;
m is 1, 2, 3, 4, or 5; and
n is 1, 2, 3, 4, or 5.
2. The compound of claim 1 , wherein:
R 1 is H or
3. The compound of claim 1 , which is
4. The compound of claim 1 , which is
5. The compound of claim 1 , which is
wherein:
m is 1, 2 or 3; and
n is 1, 2 or 3.
6. The compound of claim 1 , which is
wherein:
m is 2; and
n is 2.
7. The compound of claim 1 , which is
wherein:
m is 2; and
n is 2.
8. The compound of claim 1 , which is
wherein:
m is 2, 3, 4 or 5.
9. The compound of claim 1 , which is
wherein:
m is 2 or 3.