Y-type discrete polyethylene glycol derivative and preparation method thereof
The present invention discloses a Y-type discrete polyethylene glycol derivative, which has the advantages of determined molecular weights and the number of chain segments, and can avoid the defect of heterogeneity of a PEG derivative. In addition, the Y-type discrete polyethylene glycol derivative of the present invention may increase the water solubility of the discrete polyethylene glycol, and solve the problem of insufficient water solubility of the discrete polyethylene glycol-modified insoluble drug caused by an increase of the loading capacity.
1. A Y-type discrete polyethylene glycol derivative having the structure of formula (I):
wherein:
in and n are integer of 0-30;
A and B are the same or different Y—X— structure;
X is a linking group selected from the group consisting of: —(CH 2 ) i —, —(CH 2 ) i NH—, —(CH 2 ) i OCOO—, —(CH 2 ) i OCONH—, —(CH 2 ) i NHCONH—, —OC(CH 2 ) i COO—, —(CH 2 ) i COO— and —(CH 2 ) i CONH—, i is an integer from 0 to 10;
Y is a reactive end group selected from the group consisting of C1-C6 alkoxy, hydroxy, amino, aminomethyl, maleimide, carboxy, mercapto group, succinimide carbonate, succinimide acetate, succinimide propionate, succinimide succinate, succinimide, dithiopyridyl, propionic acid, aldehyde group, thioester group, acryloxy, azido, glutaric acid, hydrazide, alkynyl, p-nitrophenyl carbonate, isocyanato, silane, and carboxymethyl;
E 1 is a discrete polyethylene glycol group with a structure of (CH 2 CH 2 O) j , and j is an integer of 1 to 100;
and, E 2 is a discrete polyethylene glycol group with a structure of (CH 2 CH 2 O) k , and k is an integer of 1 to 100.
2. The Y-type discrete polyethylene glycol derivative of claim 1 , wherein in is an integer of 2 to 10, and/or, n is an integer of 2 to 10.
3. The Y-type discrete polyethylene glycol derivative of claim 2 , wherein in is 2, 3, 4 or 5, and/or, n is 2, 3, 4 or 5.
4. The Y-type discrete polyethylene glycol derivative of claim 1 , wherein the linking group X is —(CH 2 ) i —, —(CH 2 ) i NH— or (CH 2 ) i CONH—.
5. The Y-type discrete polyethylene glycol derivative of claim 1 , wherein for the linking group X, i is 0, 1, 2, 3 or 4.
6. The Y-type discrete polyethylene glycol derivative of claim 1 , wherein the reactive group Y is selected from the group consisting of methoxy, hydroxy, amino, mercapto, carboxy, ester, aldehyde group, acrylic or maleimide.
7. The Y-type discrete polyethylene glycol derivative of claim 1 , wherein for the discrete polyethylene glycol group E 1 , j is an integer of 1 to 20; and/or,
for the discrete polyethylene glycol group E 2 , k is an integer of 1 to 20.
8. The Y-type discrete polyethylene glycol derivative of claim 7 , wherein j is an integer of 1 to 12, and/or, k is an integer of 1 to 12.
9. The Y-type discrete polyethylene glycol derivative of claim 8 , wherein j is 1, 2, 3, 4, 5, 6, 7 or 8; and/or, k is 1, 2, 3, 4, 5, 6, 7 or 8.
10. The Y-type discrete polyethylene glycol derivative of claim 1 , wherein the Y-type discrete polyethylene glycol derivative has the following structure:
11. The Y-type discrete polyethylene glycol derivative of claim 1 , wherein
the Y-type discrete polyethylene glycol derivative has the following structure with a structure of: