Contact lens packaging solutions
View Patent ↗The present invention relates to improved contact lens products which not only have an improved and sustainable wettability. The contact lens product of the invention comprises a soft hydrogel contact lens immersed and autoclaved in a packaging solution including a polyoxyethylene-polyoxybutylene block copolymer and a high molecular weight copolymer of N-vinylpyrrolidone and at least one amino-containing vinylic monomer. The present invention also provides methods for making contact lens products of the invention.
1. A contact lens packaging solution, which is a buffered saline which comprises:
(1) a surfactant which is a poly(oxyethylene)-poly(oxybutylene) block copolymer; and
(2) from about 0.1% to about 2% by weight of a lubricant which is a copolymer of N -vinylpyrrolidone and at least one amino-containing vinylic monomer, wherein the copolymer of N-vinylpyrrolidone and at least one amino-containing vinylic monomer has a molecular weight of at least 50,000 Daltons, wherein the amino-containing vinylic monomer is selected from the group consisting of alkylaminoalkylmethacrylate having 8-15 carbon atoms, alkylaminoalkylacrylate having 7-15 carbon atoms, dialkylaminoalkylmethacrylate having 8-20 carbon atoms, dialkylaminoalkylacrylate having 7-20 carbon atoms, and N-vinylalkylamide having 3-10 carbon atoms,
wherein the contact lens packaging solution has a pH of from about 6.0 to about 8.0, an osmolality of from about 200 to about 450 mOsm/kg, and a viscosity of up to about 5.0 centipoises at 25° C.,
wherein the contact lens packaging solution is capable of providing a hydrogel contact lens immersed and autoclaved in the contact lens packaging solution in a package with a sustainable wettability, wherein the sustainable wettability of the hydrogel contact lens means that the hydrogel contact lens has a wearing-induced increase in water contact angle, designated “ΔWCA wearing ” , of about 50% or less and/or a blinking-induced increase in water contact angle, designated “ΔWCA blinking ” , of about 200% or less, wherein
Δ
WCA
wearing
_
=
WCA
16
H
_
-
WCA
OOP
_
WCA
OOP
_
in which WCA OOP is the water contact angle of the hydrogel contact lens and is measured directly out of the package and WCA 16H is the water contact angle of the hydrogel contact lens and is measured after being transferred from the package to a container containing 1 mL of a phosphate buffered saline having a pH of 7.0 to 7.4 and then fully immersed and gently agitated in the phosphate buffered saline for 16 hours at 34° C., wherein
Δ
WCA
blinking
_
=
WCA
10
_
-
WCA
0
_
WCA
0
_
in which WCA 0 is the water contact angle of the hydrogel contact lens which is measured directly out of the package, and WCA 10 is the water contact angle of the hydrogel contact lens which is measured after 10-cycles of wetting/drying treatment.
2. The contact lens packaging solution of claim 1 , wherein the packaging solution comprises from about 0.001% to about 1% by weight, preferably from about 0.005% to about 0.5% by weight, and more preferably from about 0.01% to 0.1% by weight of the poly(oxyethylene)-poly(oxybutylene) block copolymer.
3. The contact lens packaging solution of claim 2 , wherein the amino-containing vinylic monomer is dimethylaminoethylmethacrylate or dimethylaminoethylacrylate.
4. The contact lens packaging solution of claim 3 , wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer is a di-block copolymer of formula (I)
(EO) m (BO) n (I)
wherein m is an integer having an average value of 10 to 1000 and n is an integer having an average value of 5 to 1000, provided that the value of m/n is from about 2:1 to about 10:1.
5. The contact lens packaging solution of claim 4 , wherein the di-block copolymer has formula (II)
wherein R is selected from the group consisting of hydrogen, methyl, ethyl, propyl and butyl; m is an integer having an average value of 10 to 1000; and n is an integer having an average value of 5 to 1000, provided that the value of m/n is from about 2:1 to about 10:1.
6. The contact lens packaging solution of claim 5 , wherein in formula (II) R is methyl; m has an average value of 45; and n has an average value of 10.
7. The contact lens packaging solution of claim 2 , wherein the poly(oxyethylene)-poly(oxybutylene) block copolymer is a di-block copolymer of formula (I)
(EO) m (BO) n (I)
wherein m is an integer having an average value of 10 to 1000 and n is an integer having an average value of 5 to 1000, provided that the value of m/n is from about 2:1 to about 10:1.
8. The contact lens packaging solution of claim 7 , wherein the di-block copolymer has formula (II)
wherein R is selected from the group consisting of hydrogen, methyl, ethyl, propyl and butyl; m is an integer having an average value of 10 to 1000; and n is an integer having an average value of 5 to 1000, provided that the value of m/n is from about 2:1 to about 10:1.
9. The contact lens packaging solution of claim 8 , wherein in formula (II) R is methyl; m has an average value of 45; and n has an average value of 10.
10. The contact lens packaging solution of claim 2 , wherein the sustainable wettability of the hydrogel contact lens means that the hydrogel contact lens has a wearing-induced increase in water contact angle, designated “αWCA wearng ” , of about 30% or less.
11. The contact lens packaging solution of claim 10 , wherein the sustainable wettability of the hydrogel contact lens means that the hydrogel contact lens also has a blinking-induced increase in water contact angle, designated “αWCA blinking ” , of about 150% or less.
12. The contact lens packaging solution of claim 2 , wherein the sustainable wettability of the hydrogel contact lens means that the hydrogel contact lens has a blinking-induced increase in water contact angle, designated “αWCA blinking ” , of about 150% or less.
13. The contact lens packaging solution of claim 3 , wherein the sustainable wettability of the hydrogel contact lens means that the hydrogel contact lens has a wearing-induced increase in water contact angle, designated “αWCA wearing ” , of about 30% or less.
14. The contact lens packaging solution of claim 13 , wherein the sustainable wettability of the hydrogel contact lens means that the hydrogel contact lens also has a blinking-induced increase in water contact angle, designated “ΔWCA blinking ” , of about 150% or less.
15. The contact lens packaging solution of claim 3 , wherein the sustainable wettability of the hydrogel contact lens means that the hydrogel contact lens has a blinking-induced increase in water contact angle, designated “αWCA blinking ” , of about 150% or less.
16. The contact lens packaging solution of claim 7 , wherein the sustainable wettability of the hydrogel contact lens means that the hydrogel contact lens has a wearing-induced increase in water contact angle, designated “αWCA wearing ” , of about 30% or less.
17. The contact lens packaging solution of claim 16 , wherein the sustainable wettability of the hydrogel contact lens means that the hydrogel contact lens also has a blinking-induced increase in water contact angle, designated “αWCA blinking ”,of about 150% or less.
18. The contact lens packaging solution of claim 7 , wherein the sustainable wettability of the hydrogel contact lens means that the hydrogel contact lens has a blinking-induced increase in water contact angle, designated “αWCA blinking ” , of about 150% or less.
19. The contact lens packaging solution of claim 5 , wherein the sustainable wettability of the hydrogel contact lens means that the hydrogel contact lens has a wearing-induced increase in water contact angle, designated “αWCA wearing ” , of about 30% or less.
20. The contact lens packaging solution of claim 19 , wherein the sustainable wettability of the hydrogel contact lens means that the hydrogel contact lens also has a blinking-induced increase in water contact angle, designated “αWCA blinking ” ,of about 150% or less.