Anti-inflammatory peptides and methods for treating inflammatory diseases
A method for preventing or treating an inflammatory disease, such as inflammatory bowel disease and Crohn disease, is presented. The method includes administering to a patient a polypeptide having the amino acid sequence of SEQ ID NO: 1, a conservative derivative or a fragment thereof, a nucleic acid sequence encoding said polypeptide, a vector comprising said nucleic acid sequence or a host cell that has been transfected, infected or transformed by said nucleic acid sequence and/or by said vector.
1. A method for treating an inflammatory bowel disease in a patient in need thereof, said method comprising administrating to said patient a therapeutically effective amount of
a host cell genetically engineered to express a nucleic acid sequence encoding a polypeptide consisting of the amino acid sequence set forth by SEQ ID NO: 10.
2. The method of claim 1 , wherein the inflammatory bowel disease is selected from the group consisting of Crohn disease, ulcerative colitis, ileitis and enteritis.
3. The method of claim 1 , wherein said inflammatory disease is Crohn disease.
4. A method for treating an inflammatory bowel disease in a patient in need thereof, said method comprising administrating to said patient a therapeutically effective amount of an isolated polypeptide consisting of the amino acid sequence set forth by SEQ ID NO: 10 formulated with a pharmaceutically acceptable carrier.
5. The method of claim 1 , wherein said inflammatory bowel disease is an inflammatory bowel disease resulting from the activation of the NFκB pathway.
6. The method of claim 4 , wherein said isolated polypeptide is isolated from the Faecalibacterium prausnitzii strain CNCM 1-4573 or from the supernatant of the Faecalibacterium prausnitzii strain CNCM 1-4573.
7. The method of claim 4 , wherein the inflammatory bowel disease is selected from the group consisting of Crohn disease, ulcerative colitis, ileitis and enteritis.
8. The method of claim 4 , wherein said inflammatory disease is Crohn disease.
9. The method of claim 4 , wherein said inflammatory bowel disease is an inflammatory bowel disease resulting from the activation of the NFκB pathway.