Rapamycin for the treatment of lymphangioleiomyomatosis
The present invention relates to methods and compositions for treating lymphangioleiomyomatosis in a human subject in need of such treatment. The methods comprise administering to the subject via inhalation an aerosol composition comprising rapamycin or a prodrug or derivative (including analog) thereof.
1. A method for treating Lymphangioleiomyomatosis in a human subject in need of such treatment, the method comprising administering to the subject by inhalation a pharmaceutical dry powder composition comprising microparticles of sirolimus, particles of a carrier, and one or more optional excipients, wherein the microparticles of sirolimus have a mean diameter of from 1 to 5 microns, and wherein the sirolimus is the only therapeutic agent in the composition.
2. The method of claim 1 , wherein the carrier is selected from the group consisting of arabinose, glucose, fructose, ribose, mannose, sucrose, trehalose, lactose, maltose, starches, dextran, mannitol, lysine, leucine, isoleucine, dipalmitylphosphatidylcholine, lecithin, polylactic acid, poly (lactic-co-glutamic) acid, and xylitol, or mixtures of any of the foregoing.
3. The method of claim 1 , wherein the administration achieves a respirable dose of from 5 to 500 micrograms of sirolimus is delivered to the lung.
4. The method of claim 1 , wherein the administration is once daily.
5. The method of claim 1 , wherein the administration achieves a blood trough level of sirolimus of less than 2 ng/ml 12 or 24 hours after administration.
6. The method of claim 1 , wherein the amount of sirolimus in the pharmaceutical dry powder composition is from 10 to 250 micrograms.
7. The method of claim 1 , wherein the amount of sirolimus in the pharmaceutical dry powder composition is from 20 to 100 micrograms.