Crystalline substituted 5-fluoro-1H-pyrazolopyridines and process for preparing
The present application relates to a novel and efficient process for preparing novel substituted 5-fluoro-1H-pyrazolopyridines of the formula (VI) which are suitable as an intermediate for production of medicaments and for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders. More particularly, the 5-fluoro-1H-pyrazolopyridines of the formula (VI) are suitable for preparation of the compound of the formula (I) which serves for production of medicaments, for production of medicaments for treatment and/or prophylaxis of cardiovascular disorders.
1. A crystalline substance compound of the formula (I) in the form of the di-dimethyl sulphoxide solvate,
wherein the x-ray diffractogram of the compound exhibits peak maxima of the 2 theta angle at 12.0, 16.6, 17.8, 18.8, 20.3, and 21.7.
2. The crystalline substance compound of claim 1 , characterized in that the IR spectrum of the compound exhibits band maxima at 1720, 1628, 1481, 1234, 1041, 1017 cm −1 .
3. A process for preparing the crystalline substance compound of claim 1 , comprising:
stirring a solution of compounds of formula (I), wherein the compounds of formula (I) are present in one or more polymorphs or as a solvate in dimethyl disulphoxide or a mixture of dimethyl sulphoxide and an inert solvent at a temperature of 20° C.-120° C., and
isolating the di-dimethyl sulphoxide solvate.