Method for healing of an infected acne lesion without scarring
Methods of treatment and dosage regimes using hydrophobic gel or foam compositions comprising a tetracycline antibiotic for accelorating the return of skin integrity and or in treating or alleviating a disorder including impetigo, acne, rosacea, a skin disease caused by a bacteria or a tetracycline antibiotic responsive disease, wherein the foam composition or gel is administered topically to a target area on a subject having the disorder and wherein the target area comprises an area of skin, or mucosa or an eye.
1. A method for healing of an infected acne lesion without scarring, comprising topically administering at least once daily an effective amount of a minocycline antibiotic foam to an infected acne lesion, wherein the minocycline antibiotic foam is produced from a foamable composition upon addition of a liquefied or compressed gas propellant, the foamable composition comprising:
(a) 60% to 90% by weight of one or more hydrophobic oils selected from the group consisting of a mineral oil, a soybean oil, a coconut oil, cyclomethicone, and a mixture of two or more thereof;
(b) a wax selected from the group consisting of a beeswax, a hydrogenated castor oil, and a mixture thereof;
(c) at least one solid fatty alcohol having a carbon chain length of 14 to 22 carbons;
(d) at least one solid fatty acid having a carbon chain length of 12 to 28 carbons; and
(e) 0.2% to 10% by weight of a minocycline; and
wherein the foamable composition does not comprise a surfactant.
2. The method of claim 1 , wherein the minocycline is present in a free base form, a salt form, a hydrate form, or a complex form.
3. The method of claim 1 , wherein the minocycline is 1 to 4% by weight of the foamable composition.
4. The method of claim 1 , wherein the at least one solid fatty alcohol is selected from the group consisting of myristyl alcohol, cetostearyl alcohol, stearyl alcohol, behenyl alcohol, and a mixture of two or more thereof.
5. The method of claim 1 , wherein the least one solid fatty acid having a carbon chain length of 12 to 28 carbons comprises stearic acid.
6. The method of claim 1 , wherein the foamable composition further comprises fumed silica.
7. The method of claim 1 , wherein the minocycline is micronized.
8. The method of claim 1 , wherein the foamable composition further comprises an additional active agent.