Data modification for predictive operations and devices incorporating same

1. A method of operating a device, the method comprising:

obtaining a sequence of measurements indicative of a condition of a user;

modifying one or more unusable measurements in the sequence using one or more other measurements in the sequence to obtain a modified sequence of measurements, wherein modifying the one or more unusable measurements comprises:

determining a gap between a preceding usable measurement for the one or more unusable measurements and a succeeding usable measurement for the one or more unusable measurements;

replacing the one or more unusable measurements by interpolating the one or more unusable measurements using the preceding usable measurement in the sequence and the succeeding usable measurement when the gap is less than a threshold; and

backfilling the one or more unusable measurements with the succeeding usable measurement when the gap is greater than the threshold;

determining a predicted value for the condition based at least in part on the modified sequence of measurements; and

operating the device in a manner that is influenced by the predicted value.

2. The method of claim 1 , the device comprising an infusion device capable of delivering fluid to the user, the fluid influencing the condition of the user, wherein operating the device comprises operating the infusion device in a manner that is influenced by the predicted value.

3. The method of claim 2 , the infusion device being capable of delivering insulin to the user, wherein:

obtaining the sequence of measurements comprises obtaining a sequence of glucose measurements;

modifying one or more unusable measurements in the sequence comprises modifying one or more unusable glucose measurements in the sequence using one or more usable glucose measurements in the sequence to obtain a modified sequence of glucose measurements;

determining the predicted value comprises determining a predicted glucose for the user at a time in the future based at least in part on the modified sequence of glucose measurements; and

operating the device comprises operating the infusion device in a manner that is influenced by the predicted glucose in the future.

4. The method of claim 3 , wherein operating the infusion device in a manner that is influenced by the predicted glucose comprises:

determining a dosage command based at least in part on a current glucose measurement in the sequence; and

adjusting the dosage command based at least in part on the predicted glucose in the future.

5. The method of claim 1 , wherein determining the predicted value comprises determining the predicted value based at least in part on a weighted sum of values of the modified sequence of measurements.

6. The method of claim 1 , the modified sequence including a current measurement for the condition, wherein determining the predicted value comprises determining the predicted value as a sum of the current measurement and a weighted sum of differences between consecutive measurements in the modified sequence that precede the current measurement.

7. The method of claim 6 , further comprising:

identifying an unusable measurement in the sequence, wherein modifying the one or more unusable measurements comprises:

replacing the unusable measurement with a value of the succeeding usable measurement in the sequence when the gap is greater than the threshold; and

when the gap is less than the threshold:

interpolating unusable measurement using the preceding usable measurement in the sequence and the succeeding usable measurement in the sequence to obtain an interpolated value; and

replacing the unusable measurement with the interpolated value.

8. A method of operating a device, the method comprising:

obtaining a sequence of measurements indicative of a condition of a user;

modifying one or more unusable measurements in the sequence using one or more other measurements in the sequence to obtain a modified sequence of measurements;

determining a predicted value for the condition based at least in part on the modified sequence of measurements, wherein determining the predicted value for the condition based at least in part on the modified sequence of measurements comprises:

determining an estimate of a trend in the sequence of measurements based at least in part on differences between consecutive measurements of the modified sequence of measurements; and

determining the predicted value for the condition of the user at a time in the future based at least in part on a current value for the condition and the estimate of the trend; and

operating the device in a manner that is influenced by the predicted value.

9. The method of claim 8 , wherein modifying one or more unusable measurements in the sequence using one or more other measurements in the sequence comprises backfilling the one or more unusable measurements with a succeeding usable measurement.

10. The method of claim 8 , wherein:

determining the estimate of the trend comprises calculating the estimate of the trend using a truncated Taylor series expansion of the equation b t =β(y t −y t-1 )+(1−β)b t-1 ;

determining the predicted value comprises determining the predicted value using the equation ŷ=y t +hb t ;

ŷ is the predicted value;

y t is equal to a most recent measurement in the sequence of measurements;

h is a prediction horizon number of measurement samples in the future;

b t is the estimate of the trend; and

β is a tuning parameter.

11. A method of operating an infusion device capable of delivering fluid to a user, the fluid influencing a physiological condition of the user, the method comprising:

obtaining a sequence of measurements indicative of the physiological condition of the user;

modifying one or more unusable measurements in the sequence using one or more other measurements in the sequence to obtain a modified sequence of measurements;

determining an estimate of a trend in the sequence of measurements based at least in part on differences between consecutive measurements of the modified sequence of measurements;

determining a predicted value for the physiological condition of the user at a time in the future based at least in part on a current value for the physiological condition and the estimate of the trend;

determining a dosage command for operating a motor of the infusion device based at least in part on the current value for the physiological condition and the predicted value for the physiological condition; and

operating the motor of the infusion device to deliver the fluid in a manner that is influenced by the predicted value.

12. The method of claim 11 , wherein modifying one or more unusable measurements in the sequence using one or more other measurements in the sequence comprises backfilling the one or more unusable measurements with a succeeding usable measurement.

13. The method of claim 11 , further comprising determining a gap between a preceding usable measurement for the one or more unusable measurements and a succeeding usable measurement for the one or more unusable measurements, wherein modifying the one or more unusable measurements comprises:

replacing the one or more unusable measurements by interpolating the one or more unusable measurements using the preceding usable measurement in the sequence and the succeeding usable measurement when the gap is less than a threshold; and

backfilling the one or more unusable measurements with the succeeding usable measurement when the gap is greater than the threshold.

14. The method of claim 11 , wherein determining the dosage command comprises:

determining the dosage command based on a difference between the current value and a target value; and

adjusting the dosage command based on the predicted value.

15. The method of claim 14 , wherein adjusting the dosage command comprises decreasing the dosage command when the predicted value is below a suspend delivery threshold value.

16. The method of claim 14 , wherein adjusting the dosage command comprises increasing the dosage command when the predicted value is above a resume delivery threshold value.

17. The method of claim 14 , wherein:

the fluid comprises insulin;

the sequence of measurements comprises a sequence of glucose measurements;

the modified sequence comprises a modified sequence of glucose measurements;

the predicted value comprises a predicted glucose for the user at the time in the future;

determining the dosage command comprises determining the dosage command based on a difference between a current glucose measurement value and a target glucose measurement value; and

adjusting the dosage command based on the predicted value comprises:

decreasing the dosage command when the predicted glucose is below a suspend delivery threshold value; and

increasing the dosage command when the predicted glucose is above a resume delivery threshold value.