IP Library Granted Patent US 10,383,562
Granted Patent B2
US 10,383,562 · App. 15/827,514 · Granted Aug 20, 2019

Measuring psychological stress from cardiovascular and activity signals

Inventors: Alexander Chan (Campbell, CA); Ravi Narasimhan (Sunnyvale, CA)
Assignee: Vital Connect, Inc.
A61B5/165A61B5/0006A61B5/0245A61B5/02405A61B5/044A61B5/04012A61B5/0456A61B5/0468A61B5/1116A61B5/1118A61B5/1123A61B5/4884
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Quick Facts
Patent No.
US 10,383,562
App. No.
15/827,514
Granted
Aug 20, 2019
Kind
B2
Abstract

A method and system for measuring psychological stress disclosed. In a first aspect, the method comprises determining R-R intervals from an electrocardiogram (ECG) to calculate a standard deviation of the R-R intervals (SDNN) and determining a stress feature (SF) using the SDNN. In response to reaching a threshold, the method includes performing adaptation to update a probability mass function (PMF). The method includes determining a stress level (SL) using the SF and the updated PMF to continuously measure the psychological stress. In a second aspect, the system comprises a wireless sensor device coupled to a user via at least one electrode, wherein the wireless sensor device includes a processor and a memory device coupled to the processor, wherein the memory device stores an application which, when executed by the processor, causes the processor to carry out the steps of the method.

Claims (23)

1. A method for adaptive function calibration, comprising:

initializing a stress feature probability density function (PDF) to a predetermined group model;

determining a resting heart rate (HR rest ) of a user during a period of low or no activity;

estimating an individual heart rate (HR) PDF;

estimating an individual standard deviation of an R-R interval (SDNN) PDF;

computing a new stress feature PDF by combining the determined HR rest and SDNN PDF; and

converting a continuous PDF SF to at least one of: a discretized probability distribution or a probability mass function (PMF SF ).

2. The method of claim 1 , wherein the initializing the stress feature PDF to the predetermined group model stress feature is by: PDF SF ˜N(μ SFgroup , σ 2 SFgroup ).

3. The method of claim 2 , wherein the notation N(μ,σ 2 ) is a normal/Gaussian distribution with mean μ and variance σ 2 .

4. The method of claim 3 , wherein the μ SFgroup and σ 2 SFgroup are predetermined from group training data.

5. The method of claim 1 , wherein the HR rest is estimated from user data.

6. The method of claim 5 , wherein the low or no activity includes sleep periods.

7. The method of claim 1 , wherein the individual HR PDF is determined by: PDF HR ˜N(HR rest +γ*σ HRindiv , σ 2 HRindiv ).

8. The method of claim 1 , wherein the individual SDNN PDF is estimated by: PDF SDNN ˜N(μ SDNNindiv , σ 2 SDNNindiv ).

9. The method of claim 1 , wherein the new stress feature PDF is computed by combining the determined HR and SDNN PDFs by: PDF SF ˜N(HR rest +γ*σ HRindiv +α*μ SDNNindiv , σ 2 HRindiv +α 2 *σ 2 SDNNindiv ).

10. The method of claim 1 , wherein the converting the continuous PDFSF is done by sampling the PDF SF within a predetermined interval and normalizing a sum to 1.

11. A non-transitory computer-readable medium storing executable instructions that, in response to execution, cause a computer to perform operations comprising:

initializing a stress feature probability density function (PDF) to a predetermined group model;

determining a resting heart rate (HR rest ) of a user during a period of low or no activity;

estimating an individual heart rate (HR) PDF;

estimating an individual standard deviation of an R-R interval (SDNN) PDF;

computing a new stress feature PDF by combining the determined HR rest and SDNN PDF; and

converting a continuous PDF SF to at least one of: a discretized probability distribution or a probability mass function (PMF s1 ).

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Jul 5, 2024
From: INNOVATUS LIFE SCIENCES LENDING FUND I, LP
To: VITAL CONNECT, INC.
Reel/Frame 068146/0132 →
SECURITY INTEREST Recorded Jul 5, 2024
From: VITAL CONNECT, INC.
To: TRINITY CAPITAL INC.
Reel/Frame 068146/0160 →
SECURITY INTEREST Recorded Jan 8, 2021
From: VITAL CONNECT, INC.
To: INNOVATUS LIFE SCIENCES LENDING FUND I, LP
Reel/Frame 054941/0651 →
RELEASE OF SECURITY INTEREST Recorded Jan 8, 2021
From: OXFORD FINANCE LLC
To: VITAL CONNECT, INC.
Reel/Frame 054941/0743 →
SECURITY INTEREST Recorded Apr 9, 2020
From: VITAL CONNECT, INC.
To: OXFORD FINANCE LLC
Reel/Frame 052354/0752 →
Continuity (3)
Continuation 15096174 · Apr 11, 2016
Division 13664199 · Oct 30, 2012
Related Publication 20180078189A1 · Mar 22, 2018
Cited By (6)
US 1,072,837 US 1,119,639 US 1,124,917 US 12,364,403 US 12,521,021 US 12,521,039