Inhibitors of protein kinases
View Patent ↗The present invention is directed to topical pharmaceutical compositions of Formula (If) or pharmaceutically acceptable salt thereof, which act as inhibitors of syk and/or JAK kinase activity. The described topical pharmaceutical compositions are useful in preventing or treating a number of conditions mediated at least in part by syk and/or JAK kinase activity.
1. A topical pharmaceutical composition comprising a compound of
Formula If
or pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable carriers,
wherein
D 1b is C 3-8 cycloalkyl;
R 1b is selected from the group consisting of
each of which is substituted with from 1 to 2 substituents independently selected from the group consisting of hydroxyl, hydroxyC 1-8 alkylene, C 1-8 alkoxyC 1-8 alkylene, C 1-8 alkylcarbonyl, carboxy and C 1-8 alkylsulfonyl;
R 2b is H or halo; and
the wavy line in the substituents of R 1b indicates the point of attachment to the rest of the molecule.
2. The topical pharmaceutical composition of claim 1 , wherein
R 1b is
3. The topical pharmaceutical composition of claim 1 , wherein R 1b is substituted with from 1 to 2 substituents independently selected from the group consisting of C 1-8 alkylcarbonyl and C 1-8 alkylsulfonyl.
4. The topical pharmaceutical composition of claim 3 , wherein R 1b is substituted with a C 1-8 alkylsulfonyl substituent.
5. The topical pharmaceutical composition of claim 3 , wherein R 1b is substituted with a C 1-8 alkylcarbonyl substituent.
6. The topical pharmaceutical composition of claim 1 , wherein R 2b is H.
7. The topical pharmaceutical composition of claim 1 , wherein said compound of Formula If has the formula
or a pharmaceutically acceptable salt thereof.
8. The topical pharmaceutical composition of claim 1 , wherein said compound of Formula If has the formula
or a pharmaceutically acceptable salt thereof.
9. The topical pharmaceutical composition of claim 1 , wherein said topical pharmaceutical composition is in the form of an emulsion, a lotion, a gel, a foam, a cream, a jelly, a solution, a suspension, an ointment, or a transdermal patch.
10. The topical pharmaceutical composition of claim 9 , wherein said topical pharmaceutical composition is in the form of an ointment.
11. The topical pharmaceutical composition of claim 9 , wherein said topical pharmaceutical composition is in the form of a lotion or a cream.
12. The topical pharmaceutical composition of claim 1 , wherein said topical pharmaceutical composition is suspended or dissolved in said one or more carriers.
13. The topical pharmaceutical composition of claim 12 , wherein said one or more carriers is selected from the group consisting of mineral oil, liquid petrolatum, white petrolatum, propylene glycol, polyoxyethylene, polyoxypropylene compound, emulsifying wax, sorbitan monostearate, polysorbate 60, cetyl esters, wax, cetyl alcohol, 2-octyldodecanol, benzyl alcohol and water.