IP Library Patent Application 15829416
Patent Application
App. No. 15/829,416

ASPIRATION AND MECHANICAL THROMBECTOMY METHODS

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Quick Facts
Patent No.
US None
App. No.
15/829,416
Abstract

Vascular treatment and methods include a plurality of self-expanding bulbs and a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Joints between woven structures and hypotubes include solder. Woven structures include patterns of radiopaque filaments measurable under x-ray. Structures are heat treated to include at least shapes at different temperatures. A catheter includes a hypotube including interspersed patterns of longitudinally spaced rows of kerfs. Heat treating systems include a detachable flange. Laser cutting systems include a fluid flow system.

Claims (48)

1 . (canceled)

2 . A method of treating a thrombus in a vessel with combination mechanical thrombectomy and aspiration, the method comprising:

advancing a guide catheter in the vessel;

advancing a microcatheter through the guide catheter in the vessel;

advancing a thrombectomy device through the microcatheter in the vessel, the thrombectomy device including:

a plurality of self-expanding bulbs; and

a delivery device coupled to the plurality of self-expanding bulbs,

wherein advancing the thrombectomy device includes crossing the thrombus with a distal-most bulb of the plurality of self-expanding bulbs;

retracting the microcatheter and expanding at least some of the plurality of self-expanding bulbs from a radially compressed state to a radially expanded state, wherein retracting the microcatheter is at least until a distal end of the microcatheter is proximal to the thrombus;

entrapping the thrombus in at least some of the plurality of self-expanding bulbs in the radially expanded state; and

at least partially simultaneously:

retracting the microcatheter and the thrombectomy device into the guide catheter; and

applying negative suction pressure to the guide catheter.

3 . The method of claim 2 , wherein the vessel comprises a blood vessel in a brain or a blood vessel in a leg.

4 . The method of claim 2 , wherein applying the negative suction pressure to the guide catheter comprises using a syringe.

5 . The method of claim 2 , further comprising torsionally rasping the thrombectomy device including entrapping the thrombus in the plurality of self-expanding bulbs.

6 . The method of claim 2 , wherein the plurality of self-expanding bulbs comprises at least three self-expanding bulbs, at least two self-expanding bulbs of the at least three self-expanding bulbs having different outer diameters in the radially expanded state, and wherein the thrombectomy device comprises:

a plurality of necks longitudinally between and radially inward of the plurality of self-expanding bulbs, and

a distal neck radially inward of a distal-most bulb of the plurality of self-expanding bulbs.

7 . The method of claim 2 , wherein expanding the at least some of the plurality of self-expanding bulbs from the radially compressed state to the radially expanded state comprises expanding the vessel by 0% to 30%.

8 . A method of treating a thrombus in a vessel with combination mechanical thrombectomy and aspiration, the method comprising:

advancing a microcatheter in the vessel;

advancing a thrombectomy device through the microcatheter in the vessel, the thrombectomy device including a woven structure, wherein advancing the thrombectomy device includes crossing the thrombus with a distal end of the woven structure;

expanding a portion of the woven structure from a radially compressed state to a radially expanded state, wherein retracting the microcatheter is at least until a distal end of the microcatheter is proximal to the thrombus;

entrapping the thrombus in at least some of the woven structure;

retracting the microcatheter and the thrombectomy device; and

while retracting the microcatheter and the thrombectomy device, applying negative suction pressure to the vessel.

9 . The method of claim 8 , wherein the vessel comprises a blood vessel in a brain or a blood vessel in a leg.

10 . The method of claim 8 , wherein applying the negative suction pressure to the vessel comprises using a syringe.

11 . The method of claim 8 , further comprising torsionally rasping the thrombectomy device including entrapping the thrombus in the woven structure.

12 . The method of claim 8 , wherein the woven structure comprises at least three self-expanding bulbs, at least two self-expanding bulbs of the at least three self-expanding bulbs having different outer diameters in the radially expanded state, and wherein the thrombectomy device comprises:

a plurality of necks longitudinally between and radially inward of the plurality of self-expanding bulbs, and

a distal neck radially inward of a distal-most bulb of the plurality of self-expanding bulbs.

13 . The method of claim 8 , wherein expanding the portion of the woven structure from the radially compressed state to the radially expanded state comprises expanding the vessel by 0% to 30%.

14 . A method of treating a thrombus in a vessel with combination mechanical thrombectomy and aspiration, the method comprising:

advancing a thrombectomy device in the vessel, wherein advancing the thrombectomy device includes crossing the thrombus;

entrapping the thrombus in the thrombectomy device; and

retracting the thrombectomy device; and

while retracting the thrombectomy device, applying negative suction pressure to the vessel.

15 . The method of claim 14 , wherein the vessel comprises a blood vessel in a brain or a blood vessel in a leg.

16 . The method of claim 14 , wherein applying the negative suction pressure to the vessel comprises using a syringe.

17 . The method of claim 14 , wherein the thrombectomy device comprises a woven structure.

18 . The method of claim 14 , further comprising torsionally rasping the thrombectomy device including entrapping the thrombus in the portion of the thrombectomy device.

19 . The method of claim 14 , wherein the thrombectomy device comprises a woven structure comprising at least three self-expanding bulbs, at least two self-expanding bulbs of the at least three self-expanding bulbs having different outer diameters in the radially expanded state, and wherein the thrombectomy device comprises:

a plurality of necks longitudinally between and radially inward of the plurality of self-expanding bulbs, and

a distal neck radially inward of a distal-most bulb of the plurality of self-expanding bulbs.

20 . The method of claim 19 , wherein the thrombectomy device comprises a delivery device coupled to the woven structure, the delivery device comprising a multi-filament structure.

21 . The method of claim 14 , comprising expanding the vessel by 0% to 30%.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Sep 9, 2021
From: KNOBBE, MARTENS, OLSON & BEAR, LLP
To: INSERA THERAPEUTICS, INC.
Reel/Frame 057454/0677 →
SECURITY INTEREST Recorded Jun 30, 2020
From: INSERA THERAPEUTICS, INC.
To: KNOBBE, MARTENS, OLSON & BEAR, LLP
Reel/Frame 053095/0350 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 1, 2017
From: JANARDHAN, VALLABH; JANARDHAN, VIKRAM
To: INSERA THERAPEUTICS, INC.
Reel/Frame 044278/0130 →