Treatment and diagnosis of inflammatory disorders and HIV
View Patent ↗This invention concerns compositions and methods of treating or diagnosing inflammatory disorders and other disorders, as well as compositions and methods of treating HIV.
1. A method of treating an inflammatory autoimmune disease characterized by an influx of immune cells into the central nervous system, the method consisting essentially of administering to a subject in need thereof, a therapeutically effective amount of a leukotoxin comprising SEQ ID NO: 1, wherein the inflammatory autoimmune disease is multiple sclerosis which is characterized by upregulated expression of leukocyte function antigen-1 (LFA-1) on the surface of activated immune cells from blood and cerebrospinal fluid of the subject, wherein the leukotoxin depletes and/or blocks the activated immune cells in the central nervous system of the subject.
2. The method of claim 1 , wherein the leukotoxin is prepared from Aggregatibacter actinomycetemcomitans.
3. A method of treating an inflammatory autoimmune disease characterized by an influx of immune cells into the central nervous system, the method consisting of administering to a subject in need thereof a therapeutically effective amount of a leukotoxin comprising SEQ ID NO: 1, wherein the inflammatory autoimmune disease is multiple sclerosis which is characterized by upregulated expression of leukocyte function antigen-1 (LFA-1) on the surface of activated immune cells from blood and cerebrospinal fluid of the subject, wherein the leukotoxin depletes and/or blocks the activated immune cells in the central nervous system of the subject.
4. The method of claim 2 , wherein the leukotoxin is prepared from Aggregatibacter actinomycetemcomitans.