CORE STABILIZED MICROCAPSULES, METHOD OF THEIR PREPARATION AND USES THEREOF
The present invention provides core-stabilized microcapsules, wherein said core comprises at least one active agent encapsulated within a metal oxide shell, processes for their preparations, comparisons comprising them and uses thereof.
1 . Microcapsules comprising a core encapsulated by a metal oxide shell, wherein said core has a viscosity of between about 300 cP to about 1,000,000 cP and comprises at least one active agent and at least one phase changing material; wherein the thickness of said metal oxide shell is in the range 0.1-10 micron; and wherein said shell is obtained from (a) metal oxide nanoparticles, and (b) a hydrolyzed and polymerized sol gel precursor.
2 . The microcapsules according to claim 1 , wherein said at least one phase changing material is selected from natural or synthetic paraffin, aliphatic alcohols, fatty acids or any combination thereof.
3 . The microcapsule according to claim 1 , wherein said at least one active agent is selected form a pharmaceutical agent, a cosmetical agent and an agrochemical agent.
4 . The microcapsules according to claim 1 , wherein said core comprises a dermatological agent.
5 . The microcapsules of claim 1 , wherein said core comprises a dermatological agent selected from anti-fungal agents, anti-bacterial agents, anti-inflammatory agents, anti-pruritic agents, anti-psoriatic agent, anti-acne agents, anti-rosacea agents, and any combinations thereof.
6 . The microcapsules of claim 5 , wherein said anti-acne agent is selected from benzoyl peroxide, retinoid, and mixtures thereof.
7 . The microcapsules according to claim 1 , capable of being stable for a period of between about 2 weeks to about 2 years at room temperature.
8 . A composition comprising microcapsules comprising a core encapsulated by a metal oxide shell, wherein said core has a viscosity of between about 300 cP to about 1,000,000 cP and comprises at least one active agent and at least one phase changing material; wherein the thickness of said metal oxide shell is in the range 0.1-10 micron; and wherein said shell is obtained from (a) metal oxide nanoparticles, and (b) a hydrolyzed and polymerized sol gel precursor.
9 . A method for treating a surface condition in a subject in need thereof, said method comprising topically administering to said subject a composition according to claim 8 .
10 . The method of claim 9 , wherein said surface is skin or mucosal membrane.
11 . The method of claim 9 , wherein said surface condition is a skin disease, disorder or condition selected from acne, infection, inflammation, pruritis, psoriasis, seborrhea, contact dermatitis, rosacea, and a combination thereof.