GASTROINTESTINAL TRACT DETECTION METHODS, DEVICES AND SYSTEMS

1 . A device, comprising:

a sampling chamber; and

a composition in the sampling chamber,

wherein:

the composition comprises a plurality of donor particles and a plurality of acceptor particles,

each donor particle comprises a photosensitizer coupled to a first analyte-binding agent that binds to an analyte,

in an excited state, the photosensitizer generates singlet oxygen;

each acceptor particle comprises a chemiluminescent compound coupled to a second analyte-binding agent that binds to the analyte;

the chemiluminescent compound reacts with singlet oxygen to emit luminescence; and

the device is an ingestible device.

2 .- 87 . (canceled)

88 . The device of claim 1 , wherein the composition further comprises an aqueous medium comprising the donor and acceptor particles.

89 . The device of claim 2 , wherein the donor and acceptor particles are suspended in the aqueous medium.

90 . The device of claim 1 , wherein the acceptor particles comprise particles selected from the group consisting of latex particles, lipid bilayers, oil droplets, silica particles, and metal sols.

91 . The device of claim 1 , wherein the acceptor particles comprise latex particles.

92 . The device of claim 1 , wherein the chemiluminescent compound comprises a compound selected from the group consisting of Chemiluminescer, Thioxene+Diphenyl anthracence, Thioxene+Umbelliferone derivative, Thioxene+Europium chelate, Thioxene+Samarium Chelate, Thioxene+terbium Chelate, N-Phenyl Oxazine+Umbelliferone derivative, N-Phenyl Oxazine+Europium chelate, N-phenyl Oxazine+Samarium Chelate, N-phenyl Oxazine+terbium Chelate, Dioxene+Umbelliferone derivative, Dioxene+Europium chelate, Dioxene+Samarium Chelate, and N-phenyl Oxazine+terbium Chelate.

93 . The device of claim 1 , wherein the donor particles comprise particles selected from the group consisting of latex particles, lipid bilayers, oil droplets, silica particles, and metal sols.

94 . The device of claim 1 , wherein the donor particles comprise latex particles.

95 . The device of claim 1 , wherein the photosensitizer comprises a material selected from the group consisting of a dye, an aromatic compound, an enzyme, and a metal salt.

96 . The device of claim 1 , wherein a ratio of a number of the donor particles to a number of the acceptor particles in the composition is between 10:1 to 10:1.

97 . The device of claim 1 , wherein the first analyte-binding agent and/or the second analyte-binding agent is an antigen-binding agent.

98 . The device of claim 1 , wherein the first analyte-binding agent and/or the second analyte-binding agent is an antibody.

99 . The device of claim 1 , wherein the device is configured detect the analyte in vivo.

100 . The device of claim 1 , wherein the sampling chamber is configured to house an absorptive material.

101 . The device of claim 1 , wherein the analyte comprises a biomolecule, a microorganism, a therapeutic agent, a drug, a biomarker, a pesticide, a pollutant, a fragment thereof, or a metabolite thereof.

102 . The device of claim 1 , wherein the analyte is a bile acid or a bile acid salt.

103 . The device of claim 1 , wherein the analyte is an antibiotic.

104 . The device of claim 1 , wherein the analyte is associated with a disease, a disorder, or a pathogen.

105 . A device, comprising:

a sampling chamber; and

a composition in the sampling chamber,

wherein the composition comprises:

a. a first analyte-binding agent comprising a first fluorescent dye, wherein the first analyte-binding agent is capable of binding to an analyte; and

b. a second analyte-binding agent comprising a second fluorescent dye, wherein the second analyte-binding agent is capable of binding to the analyte, and wherein the second fluorescent dye exhibits increased fluorescence when spatially proximal to the first fluorescent dye; and

wherein the device is an ingestible device.

106 . A device, comprising:

a sampling chamber; and

a composition in the sampling chamber,

wherein the composition comprises:

a. a first analyte-binding agent comprising a photosensitizer, wherein the first analyte-binding agent is capable of binding to an analyte, and wherein the photosensitizer generates singlet oxygen in an excited state; and

b. a second analyte-binding agent comprising a fluorogenic dye, wherein the fluorogenic dye emits fluorescence upon reacting with singlet oxygen; and

wherein the device is an ingestible device.