IP Library › Granted Patent US 10,118,931
Granted Patent B2
US 10,118,931 · App. 15/835,758 · Granted Nov 6, 2018

CARM1 inhibitors and uses thereof

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Quick Facts
Patent No.
US 10,118,931
App. No.
15/835,758
Granted
Nov 6, 2018
Kind
B2
Abstract

Provided herein are compounds of Formula (I): and pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, wherein X, R 1 , R 1a , R 2a , R 2b , R 2c , R 2d , are as defined herein, and Ring HET is a 6-membered monocyclic heteroaryl ring system of Formula: wherein L 2 , R 13 , G 8 , G 10 , G 11 , and G 12 are as defined herein. Compounds of the present invention are useful for inhibiting CARM1 activity. Methods of using the compounds for treating CARM1-mediated disorders are also described.

Claims (5)

1. A compound which is:

or a pharmaceutically acceptable salt thereof.

2. A compound which is:

3. A pharmaceutical composition comprising the compound or pharmaceutically acceptable salt according to claim 1 , and a pharmaceutically acceptable excipient.

4. A pharmaceutical composition comprising the compound according to claim 2 , and a pharmaceutically acceptable excipient.

Assignments (3)
TERMINATION AND RELEASE OF SECURITY INTEREST IN PATENTS AT REEL/FRAME: 051057/0848 Recorded Aug 13, 2022
From: BIOPHARMA CREDIT PLC
To: EPIZYME, INC.
Reel/Frame 061165/0501 →
SECURITY INTEREST Recorded Nov 19, 2019
From: EPIZYME, INC.
To: BIOPHARMA CREDIT PLC
Reel/Frame 051057/0848 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 19, 2018
From: CHESWORTH, RICHARD; MORADEI, OSCAR MIGUEL; JIN, LEI; SHAPIRO, GIDEON; BABINE, ROBERT E.
To: EPIZYME, INC.
Reel/Frame 047106/0597 →