Pendant amines and derivatives as inhibitors of leukotriene A4 hydrolase
View Patent ↗This present disclosure is directed to compounds of formula (I): where R 1a , R 1b , R 1c , R 1d , R 1e , R 3 , R 4a , R 4b , R 4c , R 4d , R 6 , R 7 , and R 8 are described herein, as single stereoisomers or as mixtures of stereoisomers, or pharmaceutically acceptable salts, solvates, clathrates, polymorphs, ammonium ions, N-oxides or prodrugs thereof; which are leukotriene A 4 hydrolase inhibitors and therefore useful in treating inflammatory disorders. Pharmaceutical compositions including the compounds described herein and methods of preparing the compounds described herein are also provided.
1. A compound selected from a formula in the Table below:
Compound
Compound Formula
Name
4-amino- N 1 -(4- phenoxy- phenyl) pentane- diamide
2-amino- N 1 -(2- chloro- ethyl)- N 5 -(4- phenoxy- phenyl) pentane- diamide
methyl N 5 -(4- (4-(1H- pyrrol-1- yl) phenoxy) phenyl) gluta- minate
(2R)-2- amino- N-(4- phenoxy- phenyl) pentane- diamide
methyl 3-{[(2R)- 2-amino- 4-[(4- phenoxy- phenyl) carba- moyl] butyl] carba- moyl} propan- oate
(2R)-2- amino-N- {4-[4- (1H- pyrrol-1- yl) phenoxy] phenyl)- N′-[2- (pyrrolidin- 1-yl)ethyl] pentano- diamide
(2S)-2- amino-N- [2- (pyridin- 2-yl)ethyl]- N′-{4-(4- (1H-pyrrol- 1-yl) phenoxy] phenyl} pentane- diamide
(2R)-2- amino-N- [2-(1H- imidazol- 5-yl) ethyl]-N′- {4-[4- (1H- pyrrol-1- yl) phenoxy) phenyl} pentane- diamide
ethyl 3- [(2R)-2- amino-4- [(4- phenoxy- phenyl) carbamoyl] butanamido] propanoate
methyl (2S)-2- amino-4- {[4- (phenyl- amino) phenyl] carbamoyl} butanoate.
2. A compound of the following formula
3. A compound of the following formula
4. A compound of the following formula
5. A compound of the following formula
6. A compound of the following formula
7. A compound of the following formula
8. A compound of the following formula
9. A compound of the following formula
10. A compound of the following formula
11. A compound of the following formula