IP Library Granted Patent US 10,111,852
Granted Patent B2
US 10,111,852 · App. 15/838,444 · Granted Oct 30, 2018

Method for treating bladder cancer

Inventor: Michael E. Silver (Lake City, MI)
Assignee: The William M. Yarbrough Foundation
A61K31/26A61K9/0014A61K31/16A61K31/195A61K31/198
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Quick Facts
Patent No.
US 10,111,852
App. No.
15/838,444
Granted
Oct 30, 2018
Kind
B2
Abstract

A method for treating bladder cancer including the steps of administering an isothiocyanate functional surfactant to an area affected by bladder cancer, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.

Claims (16)

1. A method for treating bladder cancer, comprising the step(s) of:

administering an isothiocyanate functional surfactant to an area affected by bladder cancer, wherein the isothiocyanate functional surfactant comprises at least one isothiocyanate functional group associated with an aliphatic and/or aromatic carbon atom of the isothiocyanate functional surfactant.

2. The method for treating bladder cancer, according to claim 1 , further comprising the step of administering an additional surfactant, wherein the additional surfactant is selected from at least one of the group comprising a non-ionic surfactant, an anionic surfactant, a cationic surfactant, a zwitterionic surfactant, and combinations thereof.

3. The method for treating bladder cancer, according to claim 1 , wherein the bladder cancer is selected from one of the groups comprising urothelial carcinoma, transitional cell carcinoma, papillary carcinomas, flat carcinoma, squamous cell carcinoma, adenocarcinoma, small cell carcinoma, and sarcoma.

4. The method for treating bladder cancer, according to claim 3 , further comprising the step of administering an additional surfactant, wherein the additional surfactant is selected from at least one of the group comprising a non-ionic surfactant, an anionic surfactant, a cationic surfactant, a zwitterionic surfactant, and combinations thereof.

5. A method for treating bladder cancer, comprising the step(s) of:

administering a lysine derivative to an area affected by bladder cancer, wherein the lysine derivative comprises an α-nitrogen and a ε-nitrogen, and wherein an alkyl and/or alkanoyl substituent comprising at least approximately 8 carbon atoms is associated with the α-nitrogen, and further wherein at least one isothiocyanate functional group is associated with the ε-nitrogen.

6. The method for treating bladder cancer, according to claim 5 , further comprising the step of administering a surfactant, wherein the surfactant is selected from at least one of the group comprising a non-ionic surfactant, an anionic surfactant, a cationic surfactant, a zwitterionic surfactant, and combinations thereof.

7. The method for treating bladder cancer, according to claim 6 , wherein the bladder cancer is selected from one of the groups comprising urothelial carcinoma, transitional cell carcinoma, papillary carcinomas, flat carcinoma, squamous cell carcinoma, adenocarcinoma, small cell carcinoma, and sarcoma.

8. The method for treating bladder cancer, according to claim 5 , further comprising the step of administering a surfactant, wherein the surfactant is selected from at least one of the group comprising a non-ionic surfactant, an anionic surfactant, a cationic surfactant, a zwitterionic surfactant, and combinations thereof.

9. A method for treating bladder cancer, comprising the step(s) of:

administering a surfactant or a pharmaceutically acceptable salt thereof to an area affected by bladder cancer, wherein the protonated form of the surfactant is represented by the following chemical structure:

wherein R 1 is selected from the group consisting of an alkyl group containing 1 to 25 carbon atom(s); wherein R 2 is selected from the group consisting of NCS; and wherein R 3 -R 5 are each independently selected from the group consisting of H; OH; and an alkyl, and alkanoyl group containing 1 to 25 carbon atom(s) with the proviso that at least one of R 3 -R 5 is selected from the group consisting of an alkyl, and alkanoyl, group containing 8 to 25 carbon atoms.

10. The method for treating bladder cancer, according to claim 9 , further comprising the step of administering an additional surfactant, wherein the additional surfactant is selected from at least one of the group comprising a non-ionic surfactant, an anionic surfactant, a cationic surfactant, a zwitterionic surfactant, and combinations thereof.

11. The method for treating bladder cancer, according to claim 10 , wherein the bladder cancer is selected from one of the groups comprising urothelial carcinoma, transitional cell carcinoma, papillary carcinomas, flat carcinoma, squamous cell carcinoma, adenocarcinoma, small cell carcinoma, and sarcoma.

12. The method for treating bladder cancer, according to claim 9 , further comprising the step of administering an additional surfactant, wherein the additional surfactant is selected from at least one of the group comprising a non-ionic surfactant, an anionic surfactant, a cationic surfactant, a zwitterionic surfactant, and combinations thereof.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 30, 2018
From: SILVER, MICHAEL E.
To: THE WILLIAM M YARBROUGH FOUNDATION
Reel/Frame 045937/0561 →
Continuity (7)
Continuation 15423869 · Feb 3, 2017
Continuation In Part 14867626 · Sep 28, 2015
Continuation 14867585 · Sep 28, 2015
Continuation 14519510 · Oct 21, 2014
Continuation 13952236 · Jul 26, 2013
Provisional Application 61676093 · Jul 26, 2012
Related Publication 20180098958A1 · Apr 12, 2018
Cited By (3)
US 12,239,626 US 12,310,939 US 12,466,789