IP Library › Patent Application 15839741
Patent Application
App. No. 15/839,741

OPTIMIZED Fc VARIANTS

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Quick Facts
Patent No.
US None
App. No.
15/839,741
Abstract

The present invention relates to Fc variants having decreased affinity for FcγRIIb, methods for their generation, Fc polypeptides comprising optimized Fc variants, and methods for using optimized Fc variants.

Claims (3)

1 . (canceled)

2 . A protein comprising an Fc variant of parent Fc polypeptide, said Fc variant comprising an amino acid substitution in the Fc region selected from 267D and 267E, and wherein numbering is according to the EU index.

3 . A protein comprising an Fc variant of a human IgG1 Fc polypeptide, said Fc variant comprising an amino acid substitution in the Fc region selected from P228E, P228G, P228K and P228Y, wherein numbering is according to the EU index.

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 19, 2019
From: LAZAR, GREGORY ALAN; DANG, WEI; DESJARLAIS, JOHN R.; KARKI, SHER BAHADUR; VAFA, OMID; HAYES, ROBERT
To: XENCOR, INC.
Reel/Frame 050093/0843 →