Granted Patent B2

US 11,109,773 · App. 15/840,191 · Granted Sep 7, 2021

Inventors: Noa Urman (Pardes Hanna Carcur, IL); Zeev Bomzon (Kiryat Tivon, IL)

Assignee: Novocure GmbH

A61B5/055A61B5/0042A61N1/0476A61N1/32A61N1/36002A61N1/36025A61N1/40G06F30/20G16H20/40G16H30/40G16H50/20G16H50/50A61B5/053A61B2576/026A61N1/0456A61N1/0529A61N1/08G16H50/00

Abstract

Claims (57)

1. A method for improving treatment of a tumor using Tumor Treating Fields (TTFields), the method comprising:

receiving, by a processor of a computer system, a three-dimensional image of a body area of a patient;

identifying portions of the image that correspond to abnormal tissue;

generating a data set corresponding to the image with the abnormal tissue masked out;

retrieving a model template from a memory device of the computer system, the model template comprising tissue probability maps that specify positions of a plurality of tissue types in a corresponding body area of a healthy individual that is distinct from the patient;

deforming the model template in space so that features in the deformed model template line up with corresponding features in the data set;

modifying portions of the deformed model template that correspond to the masked-out portion of the data set so that the modified portions represent the abnormal tissue;

generating a model of electrical properties of tissues in the body area based on (a) the positions of the plurality of tissue types in the deformed and modified model template and (b) a position of the abnormal tissue in the deformed and modified model template;

determining an electrode placement layout that maximizes field strength in at least a portion of the abnormal tissue by using the model of electrical properties to simulate electromagnetic field distributions in the body area caused by simulated electrodes placed at a plurality of different sets of candidate positions respective to the body area, and selecting one of the sets;

placing the electrodes respective to the body area of the patient based on the determined electrode placement layout; and

using the placed electrodes to apply TTFields to the body area.

2. An electrotherapeutic treatment device comprising a processor configured to execute instructions stored in one or more memory devices to perform an electrotherapeutic treatment comprising:

receiving, by the processor, a three-dimensional image of a body area of a patient;

identifying portions of the image that correspond to abnormal tissue;

generating a data set corresponding to the image with the abnormal tissue masked out;

retrieving a model template from the one or more memory devices, wherein the model template specifies positions of a plurality of tissue types in a corresponding body area of a healthy individual that is distinct from the patient;

deforming the model template in space so that features in the deformed model template line up with corresponding features in the data set;

modifying portions of the deformed model template that correspond to the masked-out portion of the data set so that the modified portions represent the abnormal tissue;

generating a model of electrical properties of tissues in the body area based on (a) the positions of the plurality of tissue types in the deformed and modified model template and (b) a position of the abnormal tissue in the deformed and modified model template;

determining an electrode placement layout that maximizes field strength in at least a portion of the abnormal tissue by using the model of electrical properties to simulate electromagnetic field distributions in the body area caused by simulated electrodes placed at a plurality of different sets of candidate positions respective to the body area, and selecting one of the sets; and

outputting the determined electrode placement layout for subsequent use as a guide for placing electrodes respective to the body area of the patient prior to use of the electrodes for electrotherapeutic treatment.

3. A method for improving an electrotherapeutic treatment comprising:

receiving, by a processor of a computer system, a three-dimensional image of a body area of a patient;

identifying portions of the image that correspond to abnormal tissue;

generating a data set corresponding to the image with the abnormal tissue masked out;

retrieving a model template from a memory device of the computer system, wherein the model template specifies positions of a plurality of tissue types in a corresponding body area of a healthy individual that is distinct from the patient;

deforming the model template in space so that features in the deformed model template line up with corresponding features in the data set;

modifying portions of the deformed model template that correspond to the masked-out portion of the data set so that the modified portions represent the abnormal tissue;

generating a model of electrical properties of tissues in the body area based on (a) the positions of the plurality of tissue types in the deformed and modified model template and (b) a position of the abnormal tissue in the deformed and modified model template;

determining an electrode placement layout that maximizes field strength in at least a portion of the abnormal tissue by using the model of electrical properties to simulate electromagnetic field distributions in the body area caused by simulated electrodes placed at a plurality of different sets of candidate positions respective to the body area, and selecting one of the sets; and

outputting the determined electrode placement layout for subsequent use as a guide for placing electrodes respective to the body area of the patient prior to use of the electrodes for electrotherapeutic treatment.

4. The method of claim 3 , wherein the identifying of the portions of the image that correspond to the abnormal tissue comprises performing segmentation of the image.

5. The method of claim 3 , wherein the model of electrical properties of tissues comprises a model of electrical conductivity or resistivity.

6. The method of claim 3 , wherein the image comprises an MRI image, or a CT image.

7. The method of claim 3 , wherein the body area comprises a head of the patient.

8. The method of claim 3 , wherein the portions of the image that correspond to the abnormal tissue correspond to a tumor.

9. The method of claim 3 , wherein the electrotherapeutic treatment comprises Tumor Treating Fields (TTFields).

10. The method of claim 3 , wherein the model template is selected from a plurality of model templates based on similarities between the image and each of the model templates.

11. The method of claim 3 , further comprising:

placing the electrodes respective to the body area of the patient based on the determined electrode placement layout; and

using the electrodes to apply TTFields to the body area.

12. The method of claim 3 , wherein the determining of the electrode placement layout comprises:

applying a boundary condition to the simulated electrodes in each one of at least two electrode placement layouts;

solving a field distribution in the body area for each one of the at least two electrode placement layouts; and

choosing the electrode placement layout that yields the strongest field within the abnormal tissue.

13. The method of claim 12 , wherein the boundary condition corresponds to voltages or currents applied to the simulated electrodes.

14. The method of claim 3 , wherein the deforming of the model template comprises:

determining a mapping that maps the data set to a coordinate space of the model template; and

applying an inverse of the mapping to the model template.

15. The method of claim 14 , wherein the mapping is determined for points in the data set that fall outside of the masked-out portion.

16. The method of claim 14 , wherein the model template comprises tissue probability maps, wherein the mapping maps the data set to the tissue probability maps.

17. The method of claim 16 , wherein the tissue probability maps are existing tissue probability maps derived from images of multiple individuals.

18. The method of claim 16 , wherein the tissue probability maps are derived from images of the healthy individual from whom the model template has been derived.

19. The method of claim 18 , wherein the tissue probability maps are derived by simultaneously registering and segmenting the images of the healthy individual using existing tissue probability maps, and wherein the existing tissue probability maps are derived from images of multiple individuals.

20. The method of claim 16 , wherein the inverse of the mapping is applied to each one of the tissue probability maps, wherein the inverse-mapped tissue probability maps are combined into a segmented image comprising the deformed model template.

21. The method of claim 20 , wherein combining the inverse-mapped tissue probability maps includes assigning to each voxel the tissue type which has the highest probability of occupying that voxel across the inverse-mapped tissue probability maps.

22. The method of claim 20 , wherein combining the inverse-mapped tissue probability maps includes using a look-up table to assign a tissue type to each voxel that is assigned more than one tissue type across the inverse-mapped tissue probability maps.

Assignments (12)

Continuity (2)

Cited By (5)

US 12,208,275 US 12,311,167 US 12,515,045 US 12,646,609 US 12,699,453