Delivery of hydrophobic active agents from hydrophilic polyether block amide copolymer surfaces

1. A drug delivery coating for an inflatable balloon comprising

a base polymeric layer, the base polymeric layer comprising a hydrophilic polyether block amide copolymer and having a hydrophilic surface, the base polymeric layer configured to be disposed on the inflatable balloon;

a therapeutic agent layer forming an exterior surface of the drug delivery coating, the therapeutic agent layer disposed on the hydrophilic surface of the base polymeric layer and having a composition different than the base polymeric layer, the therapeutic agent layer comprising

a particulate hydrophobic therapeutic agent; and

a cationic agent;

wherein the therapeutic agent layer is configured on the exterior surface to be transferred from the hydrophilic surface to a target tissue in 15 minutes or less.

2. The drug delivery coating of claim 1 , the hydrophilic polyether block amide copolymer having a water contact angle less than or equal to 80 degrees.

3. The drug delivery coating of claim 1 , the hydrophilic polyether block amide copolymer having a water contact angle less than or equal to 70 degrees.

4. The drug delivery coating of claim 1 , the hydrophilic polyether block amide copolymer having a water contact angle less than or equal to 60 degrees.

5. The drug delivery coating of claim 1 , the hydrophilic polyether block amide copolymer comprising a water absorption at equilibrium at 20 degrees Celsius and 50% relative humidity of greater than 1.0% (ISO 62).

6. The drug delivery coating of claim 1 , the hydrophilic polyether block amide copolymer comprising a water absorption at equilibrium at 20 degrees Celsius and 50% relative humidity of 1.4% or greater (ISO 62).

7. The drug delivery coating of claim 1 , the particulate hydrophobic therapeutic agent and the cationic agent forming coated therapeutic agent particles.

8. The drug delivery coating of claim 1 , the cationic agent selected from the group consisting of cationic lipids, neutral lipids with cationic groups, and cationic polymers.

9. The drug delivery coating of claim 1 , the cationic agent selected from the group consisting of polyethyleneimine and 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP).

10. A drug delivery device comprising a drug delivery coating for an inflatable balloon, the drug delivery device comprising a substrate comprising the inflatable balloon;

a base polymeric layer, the base polymeric layer comprising a hydrophilic polyether block amide copolymer and having a hydrophilic surface, the base polymeric layer configured to be disposed on the inflatable balloon;

a therapeutic agent layer forming an exterior surface of at least a portion of the drug delivery device, the therapeutic agent layer contacting the hydrophilic surface of the substrate, the therapeutic agent layer comprising

a particulate hydrophobic therapeutic agent; and

a cationic agent; and

wherein the therapeutic agent layer is configured on the exterior surface to be transferred from the hydrophilic surface to a target tissue in 15 minutes or less.

11. The drug delivery device of claim 10 , the hydrophilic polyether block amide copolymer having a water contact angle less than or equal to 80 degrees.

12. The drug delivery device of claim 10 , the hydrophilic polyether block amide copolymer comprising a water absorption at equilibrium at 20 degrees Celsius and 50% relative humidity of greater than 1.0% (ISO 62).

13. A method of making a medical device comprising a drug delivery coating for an inflatable balloon, the method comprising:

depositing a base polymeric layer onto at least a portion of the inflatable balloon,

the base polymeric layer comprising a hydrophilic polyether block amide copolymer and having a hydrophilic surface, the base polymeric layer configured to be disposed on the inflatable balloon;

depositing a therapeutic agent layer onto at least a portion of the base polymeric layer, the therapeutic agent layer contacting the surface of the base polymeric layer, the therapeutic agent layer comprising

a particulate hydrophobic therapeutic agent; and

a cationic agent; and

wherein the therapeutic agent layer is configured on the exterior surface to be transferred from the hydrophilic surface to a target tissue in 15 minutes or less.

14. The method of claim 13 , the hydrophilic polyether block amide copolymer having a water contact angle less than or equal to 80 degrees.

15. The method of claim 13 , the hydrophilic polyether block amide copolymer comprising a water absorption at equilibrium at 20 degrees Celsius and 50% relative humidity of greater than 1.0% (ISO 62).

16. The method of claim 13 , wherein the therapeutic agent layer is deposited using a solvent that does not absorb into the hydrophilic polyether block amide copolymer.

17. A drug delivery coating for an inflatable balloon comprising

a base polymeric layer, the base polymeric layer comprising a hydrophilic polyether block amide copolymer and having a hydrophilic surface, the base polymeric layer configured to be disposed on the inflatable balloon;

a therapeutic agent layer forming an exterior surface of the drug delivery coating, the therapeutic agent layer disposed on the hydrophilic surface of the base polymeric layer and having a composition different than the base polymeric layer, the therapeutic agent layer comprising

a particulate hydrophobic therapeutic agent; and

a cationic agent;

wherein the therapeutic agent layer is configured on the exterior surface for delivery to a cell membrane and cellular components within a lipid bilayer in 5 minutes or less.

18. The drug delivery coating of claim 1 , the hydrophilic polyether block amide copolymer having a water contact angle less than or equal to 20 degrees.