Nozzles for nasal drug delivery
A nozzle for use in delivering a mixture of aerosol propellant and drug formulation. The nozzle includes a drug product inlet configured to receive a mixture of aerosolized propellant and an intranasal dosage form. The inlet is disposed at the proximal end. A nozzle body is secured to the drug product inlet. Two or more channels are disposed within the body. Two or more orifice apertures are disposed at the distal end of the nozzle.
1. A method for delivering a compound to an upper olfactory region of a nasal cavity, the method comprising:
actuating a nozzle positioned for intranasal delivery of the compound to a subject, wherein actuating the nozzle pressurizes a proximal end of the nozzle, the nozzle including a propellant chamber housing a propellant and a compound chamber housing the compound and including a check shut off valve, a body of the nozzle defining a compound channel and a propellant channel, the compound channel being disposed within the propellant channel;
transporting the compound from the compound chamber and through the compound channel, the compound channel having a proximal end and a distal end, the proximal end being configured to receive the compound, the distal end of the compound channel having an outlet orifice exiting to the nasal cavity;
transporting a propellant from the propellant chamber and through the propellant channel, the propellant channel having a proximal end and a distal end, the proximal end being configured to receive the propellant, the distal end of the propellant channel having an outlet orifice exiting to the nasal cavity, and the propellant channel fluidly isolated from the compound channel;
preventing, by the check shut off valve, propellant from flowing through the compound channel once the compound is released from the compound chamber; and
releasing the compound from the outlet orifice of the compound channel and the propellant from the outlet orifice of the propellant channel directly into the nasal cavity, wherein once exited a respective outlet orifice, the compound and the propellant form a plume having a width of 5 degrees or less to enable the plume to reach the upper olfactory region of a nasal cavity.
2. The method of claim 1 , wherein the nozzle further includes at least a second compound channel, wherein the nozzle is capable of delivering more than one compound at a time.
3. The method of claim 1 , wherein the compound is a liquid, a powder, a gas, or combinations thereof.
4. The method of claim 1 , wherein the check shut off valve comprises a ball having a diameter smaller than a diameter of the compound chamber, and wherein the ball is made of plastic.
5. The method of claim 4 , wherein preventing the propellant from flowing through the compound channel comprises causing the ball to roll to the distal end of the compound channel to a location behind an opening of the nozzle thereby preventing the propellant from flowing through the compound channel.
6. The method of claim 1 , wherein the compound channel is centered within the propellant channel.
7. A method for delivering a compound to an upper olfactory region of a nasal cavity, the method comprising:
actuating a nozzle positioned for intranasal delivery of the compound to a subject, wherein actuating the nozzle pressurizes a proximal end of the nozzle, the nozzle including a propellant chamber housing a propellant and a compound chamber housing the compound, a body of the nozzle defining a compound channel and a propellant channel, the compound channel being disposed within the propellant channel;
transporting the compound from the compound chamber and through the compound channel, the compound channel having a proximal end and a distal end, the proximal end being configured to receive the compound from the compound chamber, the distal end of the compound channel having an outlet orifice exiting to the nasal cavity;
transporting a propellant from the propellant chamber and through the propellant channel, the propellant channel having a proximal end and a distal end, the proximal end being configured to receive the propellant from the propellant chamber, the distal end of the propellant channel having an outlet orifice exiting to the nasal cavity, and the propellant channel fluidly isolated from the compound channel;
preventing propellant from flowing through the compound channel once the compound is released from the compound chamber; and
releasing the compound from the outlet orifice of the compound channel and the propellant from the outlet orifice of the propellant channel directly into the nasal cavity, wherein once exited a respective outlet orifice, the compound and the propellant form a plume having a width of 5 degrees or less to enable the plume to reach the upper olfactory region of a nasal cavity.
8. The method of claim 7 , wherein the nozzle further includes at least a second compound channel, wherein the nozzle is capable of delivering more than one compound at a time.
9. The method of claim 7 , wherein the compound is a liquid, a powder, a gas, or combinations thereof.
10. The method of claim 7 , wherein preventing propellant from flowing through the compound channel comprises preventing by a check shut off valve, the check shut off valve comprising a ball having a diameter smaller than a diameter of the compound chamber, wherein the ball is made of plastic.
11. The method of claim 10 , wherein preventing propellant from flowing through the compound channel comprises causing the ball to roll to the distal end of the compound channel to a location behind an opening of the nozzle thereby preventing the propellant from flowing through the compound channel.
12. The method nozzle of claim 7 , wherein the compound channel is centered within the propellant channel.