IP Library Granted Patent US 10,327,632
Granted Patent B2
US 10,327,632 · App. 15/844,914 · Granted Jun 25, 2019

Systems and methods for wide field-of-view optical coherence tomography

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Quick Facts
Patent No.
US 10,327,632
App. No.
15/844,914
Granted
Jun 25, 2019
Kind
B2
Abstract

An optical coherence tomography (OCT) system includes a light source configured to generate an OCT beam and a beam splitter, configured to split the OCT beam into a reference beam and an imaging beam, direct the reference beam toward a reflector, and direct the imaging beam toward a scanner. The system includes a linear actuator, such as a piezoelectric or voice coil, configured to move the reflector to adjust the length of the reference beam and the scanner, configured to scan the imaging beam onto a target surface at a plurality of scan angles, wherein the scanner and target surface are separated by a sample distance that varies at each of the scan angles. The system further includes an OCT controller comprising a processor and instructions stored on a memory, the instructions executable by the processor to cause the OCT controller to generate signals to cause the scanner to scan the imaging beam at each of the scan angles at a first scan rate, and cause the actuator to adjust the length of the reference beam during the scan synchronously with the scan rate to offset the variation in sample distance at each of the scan angles.

Claims (52)

1. An optical coherence tomography (OCT) system, comprising:

a light source, configured to generate an OCT beam;

a beam splitter, configured to:

split the OCT beam into a reference beam and an imaging beam;

direct the reference beam toward a reference reflector; and

direct the imaging beam toward a scanner;

a linear actuator, configured to move the reference reflector to adjust the length of the reference beam;

the scanner, configured to scan the imaging beam onto a target surface at a plurality of scan angles, wherein the scanner and target surface are separated by a sample distance that varies at each of the scan angles;

an OCT controller comprising a processor and instructions stored on a memory, the instructions executable by the processor to cause the OCT controller to generate signals to:

cause the scanner to scan the imaging beam at each of the scan angles at a first scan rate; and

cause the actuator to adjust the length of the reference beam during the scan synchronously with the scan rate to offset the variation in sample distance at each of the scan angles.

2. The system of claim 1 , wherein the scan rate is between 200 Hz and 400 Hz.

3. The system of claim 1 , wherein the scan rate is at least 300 Hz.

4. The system of claim 1 , wherein the scanner is configured to scan the imaging beam at each of the scan angles according to a raster pattern.

5. The system of claim 4 , wherein the raster pattern generates a B-scan at least 12 mm in length.

6. The system of claim 4 , wherein the raster pattern generates a B-scan at least 16 mm in length.

7. The system of claim 1 , wherein the linear actuator comprises a piezoelectric actuator or voice coil actuator, configured to translate the reference reflector at least 2 mm in a direction parallel to the reference beam.

8. The system of claim 1 , wherein the linear actuator comprises a piezoelectric actuator or voice coil actuator, configured to translate the reference reflector at least 4 mm in a direction parallel to the reference beam.

9. The system of claim 1 , wherein the OCT system comprises a spectral-domain OCT (SD-OCT) system or a swept-source OCT (SS-OCT) system.

10. An optical coherence tomography (OCT) system, comprising:

a light source, configured to generate an OCT beam;

a beam splitter, configured to:

split the OCT beam into a reference beam and an imaging beam;

direct the reference beam toward a reference reflector; and

direct the imaging beam toward a scanner;

a linear actuator, configured to move the reference reflector to change the length of the reference beam; and

the scanner, configured to scan the imaging beam onto a target surface over a plurality of scan angles, wherein the scanner and target surface are separated by a first sample distance at a first scan angle and a second sample distance at a second scan angle;

an OCT controller comprising a processor and instructions stored on a memory, the instructions executable by the processor to cause the OCT controller to generate signals to:

cause the scanner to scan the imaging beam onto the target surface at the first scan angle and the second scan angle according to a scan rate; and

cause the actuator to move the reference reflector synchronously with the scan rate while the scanner scans the imaging beam onto the target surface, thereby adjusting the length of the reference beam to account for a difference between the first sample distance and the second sample distance; and

a detector configured to:

receive the reference beam reflected by the reference reflector and the imaging beam reflected by the target surface; and

output an interference signal based on the received reference beam and the imaging beam.

11. The system of claim 10 , wherein the linear actuator comprises a piezoelectric stack or a voice coil actuator, configured to translate the reference reflector at least 2 mm in a direction parallel to the reference beam.

12. The system of claim 10 , wherein the first scan angle and the second scan angle are separated by at least 20 degrees.

13. The system of claim 10 , wherein the scan generates a B-scan at least 12 mm in length.

14. The OCT system of claim 10 , wherein the OCT system comprises a spectral-domain OCT (SD-OCT) system or a swept-source OCT (SS-OCT) system.

15. An optical coherence tomography (OCT) system, comprising:

a light source, configured to generate an OCT beam;

a beam splitter, configured to:

split the OCT beam into a reference beam and an imaging beam;

direct the reference beam toward a reference reflector; and

direct the imaging beam toward a scanner;

a linear actuator, configured to translate the reference reflector at least 2 mm in a direction parallel to the reference beam;

the scanner, configured to scan the imaging beam onto a target surface at a plurality of scan angles;

an OCT controller comprising a processor and instructions stored on a memory, the instructions executable by the processor to cause the OCT controller to generate signals to:

cause the scanner to scan the imaging beam at each of the scan angles at a first scan rate; and

move the actuator to translate the reference reflector synchronously with the scan rate, such that a path length of the reference beam is maintained within a tolerance range of a path length of the imaging beam throughout the scan.

16. The OCT system of claim 15 , wherein the tolerance range is less than 1 mm.

17. The system of claim 16 , wherein the scan rate is between 200 Hz and 400 Hz.

18. The system of claim 15 , wherein the scanner is configured to scan the imaging beam at each of the scan angles according to a raster pattern.

19. The system of claim 15 , wherein the linear actuator comprises a piezoelectric actuator or a voice coil actuator, configured to translate the reference reflector at least 2 mm in a direction parallel to the reference beam.

Assignments (3)
CONFIRMATORY DEED OF ASSIGNMENT EFFECTIVE APRIL 8, 2019 Recorded Dec 10, 2019
From: NOVARTIS AG
To: ALCON INC.
Reel/Frame 051454/0788 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 19, 2017
From: HORN, JOCHEN
To: ALCON RESEARCH, LTD.
Reel/Frame 044440/0233 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Dec 19, 2017
From: ALCON RESEARCH, LTD.
To: NOVARTIS AG
Reel/Frame 044440/0303 →
Cited By (1)
US 12,402,790