Antiparasitic compounds
View Patent ↗The present invention relates to isothiazoline compounds of formula (I). The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to veterinary compositions comprising said compounds.
1. A method of treating a mammal for ectoparasite infection or infestation comprising administering to a mammal the compound 1-[6-[5-(3,5-dichloro-4-fluoro-phenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]spiro[1H-isobenzofuran-3,3′-azetidine]-1′-yl]-3,3,3-trifluoro-propan-1-one or a pesticidal, veterinary, or pharmaceutically acceptable salt thereof.
2. The method of claim 1 , wherein the ectoparasite is selected from ticks, mites, chewing lice, sucking lice, fleas, biting flies, midges, mosquitos, bed bugs, grubs, and copepods.
3. The method of claim 2 , wherein the ectoparasite is selected from Ixodes spp., I. ricinus, I. hexagonus, Rhipicephalus spp., R. sanguineus, Boophilus spp., Amblyomma spp., A. americanum, A. maculatum, A. triste, A. parvum, A. cajennense, A. ovale, A. oblongoguttatum, A. aureolatum, A. cajennense, Hyalomma spp., Haemaphysalis spp., Dermacentor spp., D. variabilis, D. andersoni, D. marginatus, Ornithodorus spp., Dermanyssus spp., Sarcoptes spp., S. scabiei, Psoroptes spp., P. bovis, Otodectes spp., Chorioptes spp., Demodex spp., D. folliculorum, D. canis, D. brevis, Damalinia spp., Linognathus spp., Cheyletiella spp., Haematopinus spp., Solenoptes spp., Trichodectes spp., Felicola spp., Siphonaptera spp., Ctenocephalides spp., Tabanidae spp., Haematobia spp., Musca spp., Stomoxys spp., Dematobia spp., Cochliomyia spp., Simuliidae spp., Ceratopogonidae spp., Psychodidae spp., Aedes spp., Culex spp., Anopheles spp., Lucilia spp., Phlebotomus spp., Lutzomyia spp., insects within the genus Cimex and family Cimicidae, Hypoderma bovis, H. lineatum , or insects within the Order Siphonostomatoida, including genera Lepeophtheirus and Caligus.
4. A method of treating a mammal for endoparasite infection or infestation comprising administering to a mammal the compound 1-[6-[5-(3,5-dichloro-4-fluoro-phenyl)-5-(trifluoromethyl)-4H-isothiazol-3-yl]spiro[1H-isobenzofuran-3,3′-azetidine]-1′-yl]-3,3,3-trifluoro-propan-1-one or a pesticidal, veterinary, or pharmaceutically acceptable salt thereof.
5. The method of claim 4 , wherein the endoparasite is selected from helminths, gastrointestinal roundworms, hookworms, lungworms, eyeworms, parasitic stage grubs, kidneyworms, screw worm, and filarial nematodes of the superfamily Filarioidea and the Onchocercidae Family.
6. The method of claim 5 , wherein the endoparasite is selected from trematodes, cestodes, nematodes, heartworm, roundworm, hookworm, whipworm, fluke, tapeworm, Ostertagia ostertagi, O. lyrata, Haemonchus placei, H. similis, H. contortus, Toxocara canis, T.leonina, T. cati, Trichostrongylus axei, T. colubriformis, T. longispicularis, Cooperia oncophora, C. pectinata, C. punctata, C. surnabada (syn. mcmasteri ), C. spatula, Ascaris suum, Hyostrongylus rubidus, Bunostomum phlebotomum, Capillaria bovis, B. trigonocephalum, Strongyloides papillosus, S. ransomi, Oesophagostomum radiatum, O. dentatum, O. columbianum, O. quadrispinulatum, Trichuris spp., Ancylostoma caninum, A.tubaeforme, A.braziliense, Uncinaria stenocephala ); Dictyocaulus viviparous, Metastrongylus spp, Thelazia spp., Hypoderma bovis, H. lineatum, Dermatobia hominis, Stephanurusdentatus, Cochliomyia hominivorax, B.malayi, B. pahangi, B. timori, Wuchereria spp., W. bancrofti, Dirofilaria spp., D. immitis, D. repens, D. ursi, D. tenuis, D.spectans, D. lutrae, Dipetalonema spp., D reconditum, D. repens, Onchocerca spp., O. gibsoni, O. gutturosa, O. volvulus, Elaeophora spp., E.bohmi, E. elaphi, E. poeli, E. sagitta, E. schneideri, Mansonella spp., M. ozzardi, M. perstans, Loa spp., and L. loa.