MODULAR CHEMIRESISTIVE SENSOR
The present invention relates to methods of forming modular chemiresistive sensors. The sensors preferably have two gold or platinum electrodes mounted on a silicon substrate with the electrodes connected to a power source and are separated by a gap of 0.5 to 4.0 μm. Functionalized polymer nanowire or carbon nanotube span the gap between the electrodes and connect the electrodes electrically. The electrodes are further connected to a circuit board having a processor and data storage, where the processor measures current and voltage values between the electrodes and compares the current and voltage values with current and voltages values stored in the data storage and assigned to particular concentrations of a pre-determined substances.
1 . A method of producing a sensor comprising
forming a first and a second noble metal electrode on a silicon substrate, said electrodes separated by a gap of 0.5 to 4.0 μm, said electrodes connected to a power source and means for measuring current and/or voltage between the first and second noble metal electrodes.
forming a nano-network of functionalized nanowires or nanotubes in situ, the network of nanowires or nanotubes spanning the gap and providing an electrically conductive pathway connecting the first and second noble metal electrodes.
2 . The method of claim 1 wherein the sensor is a carbon dioxide sensor and wherein the nano-network is formed by the in-situ polymerization of an amine functionalized aniline monomer to form amine functionalized aniline polymer nanowires spanning the gap; and
using an electrochemical process, forming a nano-network of alkyl amine-modified polymer nanowires.
3 . The method of claim 2 wherein the electrochemical process uses 0.1-1.0 M of an electrolyte in water, the electrolyte selected from the group consisting of formic acid, acetic acid, perchloric acid, hydrochloric acid, phosphoric acid and nitric acid in water.
4 . The method of claim 3 wherein the electrolyte is 0.4-0.6 M nitric acid and the nano-network is formed from amine functionalized aniline monomers.
5 . The method of claim 2 wherein the electrochemical process uses an electrical current of 12-50 nanoampere for a period of 4-6 hours.
6 . The method of claim 2 wherein the nanowires have a diameter of 30 nm to 150 nm.
7 . The method of claim 1 wherein the sensor detects the presence of one or more of a disease biomarker indicating the existence of cancer, hepatitis or Alzheimer's, Parkinson's or cardiac disease, wherein the nano-network is formed by the in-situ polymerization of a monomer to form amine functionalized polymer nanowires spanning the gap and covalently attaching to the amine-modified polymer nanowires or nanotubes Aβ (amyloid β) monomers or oligomers.
8 . The method of claim 7 for formation of a sensor for Alzheimer's or cancer detection wherein the nanowires comprise electrochemically formed N-hydroxyphathalo-succinimide or functionalized N-hydroxyphathalo-succinimide polypyrrole nanowires with antibodies specific to Alzheimer's or cancer-specific proteins or biomarkers conjugated to said polypyrrole nanowires.
9 . The method of claim 1 wherein the sensor is formed from functionalized carbon nano-tubes.
10 . The method of claim 7 wherein the sensor formed is for the detection of Alzheimer's or cancer comprising carbon nanotubes functionalized by electrochemically depositing N-hydroxyphathalo-succinimide or functionalized N-hydroxyphathalo-succinimide on the surface of the nanotubes, with antibodies specific to Alzheimer's or cancer specific proteins or biomarkers conjugated to said functionalized nanowires.
11 . The method of claim 9 wherein the carbon nano-tubes are functionalized with carboxylic acid and the sensor detects the presence of mercury.