System and method for titrating in vivo cellular reaction and gene expression using varying oscillation frequencies

1. A system for directing a waveform energy toward a target tissue to modify a phenotypic differentiation of the target tissue at a cellular level, comprising:

a waveform energy generator;

a radiation unit that is in communication with the waveform energy generator and receives a waveform energy therefrom, wherein the radiation unit is positionable relative to the target tissue;

a monitor that is configured to receive data related to the phenotypic differentiation of the target tissue; and;

a controller that is in electronic communication with the monitor and at least one of the waveform energy generator and the radiation unit,

wherein the controller comprises encoded instructions comprising both a predetermined treatment protocol and a logic operation comprising termination of the predetermined treatment protocol when data received from the monitor indicates the phenotypic differentiation of the target tissue corresponds to a desired phenotypic differentiation.

2. The system of claim 1 , wherein the waveform energy is a sonic radiation having a wavelength ranging from 20 Hz to 20 kHz.

3. The system of claim 1 , wherein the waveform energy is a sonic radiation having a wavelength of less than 20 Hz to 20 kHz.

4. The system of claim 1 , wherein the waveform energy is a sonic radiation having a wavelength of greater than 20 kHz.

5. The system of claim 1 , wherein the waveform energy is an electromagnetic energy having a wavelength of 10 −25 m to 10 3 m.

6. The system of claim 1 , wherein the monitor receives data from a stepwise titration process.

7. The system of claim 6 , wherein the stepwise titration process is selected from the group consisting of polymerase chain reaction and bioelectric impedance analysis.

8. A method of modifying a phenotypic differentiation of a target tissue at a cellular level, comprising:

identifying the target tissue and a cellular structure of the target tissue;

determining a natural frequency of the target tissue;

determining a desired phenotype of the target tissue;

providing a system comprising:

a waveform energy generator;

a radiation unit that is in communication with the waveform energy generator and receives a waveform energy therefrom, wherein the radiation unit is positionable relative to the target tissue;

a monitor that is configured to receive data related to the phenotypic differentiation of the target tissue; and;

a controller that is in electronic communication with the monitor and at least one of the waveform energy generator and the radiation unit,

wherein the controller comprises encoded instructions comprising both a predetermined treatment protocol and a logic operation comprising termination of the predetermined treatment protocol when data received from the monitor indicates the phenotypic differentiation of the target tissue corresponds to a desired phenotypic differentiation;

positioning the radiation unit to direct the waveform energy towards the target tissue;

emitting the waveform energy in accordance with the predetermined treatment protocol;

using the monitor, collecting data related to the phenotypic differentiation of the target tissue and transmitting said data to the controller; and

terminating emission of the waveform energy when the phenotypic differentiation of the target tissue correspond to the desired phenotypic differentiation.

9. The method of claim 8 , wherein the predetermined protocol comprises the steps of:

adjusting the waveform energy to a frequency f;

adjusting the amplitude of the waveform energy to an intensity level v; and

providing a time duration t d , during which the waveform energy is emitted.

10. The method of claim 9 , wherein emission of the waveform energy is continuous through time duration t d .

11. The method of claim 9 , wherein emission of the waveform energy is intermittent through time duration t d .

12. The method of claim 9 , wherein adjustment of the frequency f is accomplished by alternating between a first frequency f 1 and a second frequency f 2 , wherein f 1 and f 2 are different frequencies.

13. The method of claim 12 , wherein alternation between f 1 and f 2 is performed at a predetermined repetition rate.

14. The method of claim 9 , wherein emission of the waveform energy is provided as a plurality of waveform energy pulses, wherein each one of the plurality of waveform energy pulses has a time duration t d and is separate from an adjacent one of the plurality of waveform energy pulses by a predetermined time interval t i , and wherein t i is greater than t d .

15. The method of claim 9 , further comprising the steps of:

positioning the radiation unit at a distance d from the target tissue; wherein d is greater than 10 mm; and

using the radiation unit, focusing the waveform energy on the target tissue.

16. The method of claim 9 , wherein the waveform energy is a sonic radiation having a wavelength ranging from 20 Hz to 20 kHz.

17. The method of claim 9 , wherein the waveform energy is a sonic radiation having a wavelength of less than 20 Hz to 20 kHz.

18. The method of claim 9 , wherein the waveform energy is a sonic radiation having a wavelength of greater than 20 kHz.

19. The method of claim 9 , wherein the waveform energy is an electromagnetic energy having a wavelength of 10 −25 m to 10 3 m.

20. The method of claim 9 , wherein the monitor receives data from a stepwise titration process.

21. The method of claim 9 , wherein the stepwise titration process is selected from the group consisting of polymerase chain reaction and bioelectric impedance analysis.