IP Library Granted Patent US 10,713,801
Granted Patent B2
US 10,713,801 · App. 15/862,438 · Granted Jul 14, 2020

Image registration of treatment planning image, intrafraction 3D image, and intrafraction 2D x-ray image

Inventors: Petr Jordan (Redwood City, CA); Calvin R. Maurer, Jr. (San Jose, CA); Andriy Myronenko (San Mateo, CA); Jonathan Cecil Chappelow (Campbell, CA)
Assignee: Accuray Incorporated
G06T7/337A61B6/032A61B6/4258A61B6/5223A61B6/5235A61B6/5264A61N5/1049G06T7/0014G06T7/20G06T7/248G06T7/30G06T15/08G06T15/205A61N5/103A61N2005/1062G06T2207/10072G06T2207/10124G06T2207/30004G06T2210/41
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Quick Facts
Patent No.
US 10,713,801
App. No.
15/862,438
Granted
Jul 14, 2020
Kind
B2
Abstract

A method of the present disclosure includes performing, by a processing device, a first image registration between a reference image of a patient and a motion image of the patient to perform alignment between the reference image and the motion image, wherein the reference image and the motion image include a target position of the patient. The method further includes performing, by the processing device, a second image registration between the reference image and a motion x-ray image of the patient, via a first digitally reconstructed radiograph (DRR) for the reference image of the patient. The method further includes tracking at least a translational change in the target position based on the first registration and the second registration.

Claims (70)

1. A method, comprising:

performing, by a processing device, a first image registration between a reference image of a patient and a motion image of the patient to perform alignment between the reference image and the motion image, wherein the reference image and the motion image include a target position of the patient;

performing, by the processing device, a second image registration between the reference image and a motion x-ray image of the patient, via a first digitally reconstructed radiograph (DRR) for the reference image of the patient; and

tracking at least a translational change in the target position based on the first registration anc the second registration.

2. The method of claim 1 , wherein the reference image and the motion image are three-dimensional (3D) images.

3. The method of claim 2 , wherein the reference image is a 3D planning image.

4. The method of claim 2 , wherein the reference image is one of: a kilovoltage computed tomography (kV-CT) image, a magnetic resonance imaging (MRI) image, a kilovoltage cone beam computed tomography (kV-CBCT) image, or a megavoltage computed tomography (MVCT) image.

5. The method of claim 2 , wherein the motion image is one of: a kilovoltage cone beam computed tomography (kV-CBCT) image, a megavoltage cone beam computed tomography (MV-CBCT) image, a megavoltage computed tomography (MVCT) image, or a helical kV-CT image.

6. The method of claim 1 , wherein the first image registration is used to perform a global rotational patient alignment, and wherein the second image registration is used to maintain the global rotational patient alignment.

7. The method of claim 1 , further comprising:

generating a second DRR, wherein the second DRR is of the motion image;

performing a third image registration between the motion image and the motion x-ray image via the second DRR; and

tracking at least the translational change in the target position based on the third registration.

8. The method of claim 1 , wherein the reference image, the motion image, and the motion x-ray image are generated by an imaging source of a helical radiation delivery system or by one or more imaging sources at different positions with respect to the patient.

9. The method of claim 1 , further comprising:

detecting a fiducial migration associated with the patient based on the first DRR; and

modifying a tracking algorithm associated with a treatment delivery of the patient to account for the fiducial migration.

10. A system comprising:

a memory; and

a processing device, operatively coupled with the memory, to:

performing a first image registration between a reference image of a patient and a motion image of the patient to perform alignment between the reference image and the motion image, wherein the reference image and the motion image include a target position of the patient;

performing a second image registration between the reference image and a motion x-ray image of the patient, via a first digitally reconstructed radiograph (DRR) for the reference image of the patient; and

track at least a translational change in the target position based on the first registration and the second registration.

11. The system of claim 10 , wherein the reference image is one of: a kilovoltage computed tomography (kV-CT) image, a magnetic resonance imaging (MRI) image, a kilovoltage cone beam computed tomography (kV-CBCT) image, or a megavoltage computed tomography (MVCT) image.

12. The system of claim 10 , wherein the motion image is one of: a kilovoltage cone beam computed tomography (kV-CBCT) image, a megavoltage cone beam computed tomography (MV-CBCT) image, a megavoltage computed tomography (MVCT) image, or a helical kV-CT image.

13. A non-transitory computer readable medium comprising instructions that, when executed by a processing device, cause the processing device to:

perform, by a processing device, a first image registration between a reference image of a patient and a motion image of the patient to perform alignment between the reference image and the motion image, wherein the reference image and the motion image include a target position of the patient;

perform, by the processing device, a second image registration between the reference image and a motion x-ray image of the patient, via a first digitally reconstructed radiograph (DRR) for the reference image of the patient; and

track at least a translational change in the target position based on the first registration and the second registration.

14. The non-transitory computer readable medium of claim 13 , the processing device further to:

generate a second DRR, wherein the second DRR is of the motion image;

perform a third image registration between the motion image and the motion x-ray image via the second DRR; and

track at least the translational change in the target position based on the third registration.

15. The non-transitory computer readable medium of claim 13 , wherein the reference image, the motion image, and the motion x-ray image are generated by an imaging source of a helical radiation delivery system or by one or more imaging sources at different positions with respect to the patient.

16. The non-transitory computer readable medium of claim 13 , the processing device further to:

detect a fiducial migration associated with the patient based on the first DRR; and

modify a tracking algorithm associated with a treatment delivery of the patient to account for the fiducial migration.

17. A method, comprising:

performing, by a processing device, a first image registration between a reference image of a patient and a motion image of the patient, to perform alignment between the reference image and the motion image, wherein the reference image and the motion image include a target position of the patient;

performing, by the processing device, a second image registration between the motion image and a motion x-ray image of the patient, via a first digitally reconstructed radiograph (DRR) for the motion image; and

tracking at least a translational change in the target position based on the first registration and the second registration.

18. The method of claim 17 , wherein the motion image has a higher spatial resolution than the reference image.

19. The method of claim 17 , wherein the reference image is one of: a kilovoltage computed tomography (kV-CT) image, a magnetic resonance imaging (MRI) image, a kilovoltage cone beam computed tomography (kV-CBCT) image, or a megavoltage computed tomography (MVCT) image.

20. The method of claim 17 , wherein the motion image is one of: a kilovoltage cone beam computed tomography (kV-CBCT) image, a megavoltage cone beam computed tomography (MV-CBCT) image, a megavoltage computed tomography (MVCT) image, or a helical kV-CT image.

21. The method of claim 17 , wherein the first DRR corresponds to a daily patient pose and deformation.

22. The method of claim 17 , further comprising:

detecting a fiducial migration associated with the patient based on the first DRR; and

modifying a tracking algorithm associated with a treatment delivery of the patient to account for the fiducial migration.

23. The method of claim 17 , further comprising:

performing a third image registration between an enhanced reference image and the motion x-ray image of the patient, via a second DRR, wherein the second DRR is of the enhanced reference image; and

tracking at least the translational change in the target position based on the third registration.

24. The method of claim 23 , wherein the enhanced reference image is generated by combining one or more characteristics of the reference image of the patient with one or more characteristics of the motion image.

25. A system comprising:

a memory; and

a processing device, operatively coupled with the memory, to:

perform a first image registration between a reference image of a patient and a motion image of the patient, to perform alignment between the reference image and the motion image, wherein the reference image and the motion image include a target position of the patient;

perform a second image registration between the motion image and a motion x-ray image of the patient, via a first digitally reconstructed radiograph (DRR) for the motion image; and

track at least a translational change in the target position based on the first registration and the second registration.

26. The system of claim 25 , wherein the motion image is one of: a kilovoltage cone beam computed tomography (kV-CBCT) image, a megavoltage cone beam computed tomography (MV-CBCT) image, a megavoltage computed tomography (MVCT) image, or a helical kV-CT image.

27. The system of claim 25 , the processing device further to:

detect a fiducial migration associated with the patient based on the first DRR; and

modify a tracking algorithm associated with a treatment delivery of the patient to account for the fiducial migration.

28. A non-transitory computer readable medium comprising instructions that, when executed by a processing device, cause the processing device to:

perform, by a processing device, a first image registration between a reference image of a patient and a motion image of the patient, to perform alignment between the reference image and the motion image, wherein the reference image and the motion image include a target position of the patient;

perform, by the processing device, a second image registration between the motion image and a motion x-ray image of the patient, via a first digitally reconstructed radiograph (DRR) for the motion image; and

track at least a translational change in the target position based on the first registration and the second registration.

29. The non-transitory computer readable medium of claim 28 , the processing device further to:

perform a third image registration between an enhanced reference image and the motion x-ray image of the patient, via a second DRR, wherein the second DRR is of the enhanced reference image; and

track at least the translational change in the target position based on the third registration.

30. The non-transitory computer readable medium of claim 28 , wherein the reference image, the motion image, and the motion x-ray image are generated by an imaging source of a helical radiation delivery system or by one or more imaging sources at different positions with respect to the patient.

Assignments (9)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 13, 2025
From: ACCURAY INCORPORATED
To: ACCURAY LLC
Reel/Frame 072421/0584 →
RELEASE OF SECURITY INTEREST Recorded Jun 6, 2025
From: FIRST-CITIZENS BANK & TRUST COMPANY
To: ACCURAY INCORPORATED
Reel/Frame 071638/0034 →
RELEASE OF SECURITY INTEREST Recorded May 20, 2021
From: MIDCAP FINANCIAL TRUST
To: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
Reel/Frame 056301/0491 →
RELEASE OF SECURITY INTEREST Recorded May 20, 2021
From: MIDCAP FUNDING IV TRUST (AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FUNDING X TRUST, AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FUNDING IV TRUST, AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FINANCIAL TRUST)
To: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
Reel/Frame 056301/0432 →
SECURITY INTEREST Recorded May 14, 2021
From: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
To: SILICON VALLEY BANK, AS ADMINISTRATIVE AND COLLATERAL AGENT
Reel/Frame 056247/0001 →
ASSIGNMENT OF SECURITY AGREEMENTS Recorded Mar 1, 2019
From: MIDCAP FUNDING X TRUST (AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FUNDING IV TRUST, AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FINANCIAL TRUST), AS EXISTING ADMINISTRATIVE AGENT
To: MIDCAP FUNDING IV TRUST, AS SUCCESSOR TO EXISTING ADMINISTRATIVE AGENT
Reel/Frame 048481/0804 →
SECURITY INTEREST Recorded Jul 12, 2018
From: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
To: MIDCAP FINANCIAL TRUST
Reel/Frame 046337/0107 →
SECURITY INTEREST Recorded Jul 12, 2018
From: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
To: MIDCAP FUNDING X TRUST (AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FUNDING IV TRUST, AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FINANCIAL TRUST)
Reel/Frame 046336/0932 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded May 29, 2018
From: JORDAN, PETER; MAURER, CALVIN R., JR.; MYRONENKO, ANDRIY; CHAPPELOW, JONATHAN CECIL
To: ACCURAY INCORPORATED
Reel/Frame 045914/0419 →
Continuity (2)
Provisional Application 62443581 · Jan 6, 2017
Related Publication 20180197303A1 · Jul 12, 2018
Cited By (17)
US 12,186,028 US 12,201,384 US 12,206,837 US 12,239,385 US 12,290,416 US 12,354,227 US 12,383,369 US 12,412,346 US 12,417,595 US 12,440,702 US 12,458,411 US 12,461,375 US 12,462,335 US 12,475,662 US 12,491,044 US 12,502,163 US 12,521,201