IP Library Granted Patent US 12,128,252
Granted Patent B2
US 12,128,252 · App. 15/862,461 · Granted Oct 29, 2024

No-view interfraction treatment target motion management using volumetric imaging

Inventors: Petr Jordan (Redwood City, CA); Calvin R. Maurer, Jr. (San Jose, CA)
Assignee: Accuray Incorporated
A61N5/1049A61B6/032A61B6/4258A61B6/486A61B6/50A61B6/5235A61N5/1045A61N5/1067A61N5/1069A61N5/107A61N5/1081A61N5/1083A61N2005/1055A61N2005/1061
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Quick Facts
Patent No.
US 12,128,252
App. No.
15/862,461
Filed
Jan 4, 2018
Granted
Oct 29, 2024
Kind
B2
Art Unit
3798
USPC
600/411
Abstract

A method of the present disclosure includes identifying, based on a reference image, a full motion range of a target, wherein the full motion range of the target defines a full internal target volume (ITV). The method further includes identifying a non-target object in a motion image or the reference image. The method further includes performing a volumetric alignment of the ITV and the non-target object. The method further includes modifying a non-target to target displacement vector based on the volumetric alignment. The method further includes tracking the target based on the modified non-target to target displacement vector.

Claims (33)

1. A method, comprising:

identifying, based on a reference image, a full motion range of a target, wherein the full motion range of the target defines a full internal target volume (ITV), wherein the reference image is a four-dimensional (4D) inhale and exhale planning image;

identifying a non-target object in a motion image or the reference image;

determining, based on a volumetric alignment of the ITV and the non-target object, a non-target to target displacement vector between a reference point on the non-target object and a center of the target as defined by the reference image based on the volumetric alignment, wherein the non-target to target displacement vector defines an estimated relative position of the target with respect to the non-target object; and

applying, by a processing device, the same non-target to target displacement vector at the reference point on the non-target object after each of a plurality of non-target object corrections to perform 0-view tracking of the target indirectly based on the non-target to target displacement vector without tracking the target directly in the motion image, wherein the target displacement vector is to compensate for gross motion of the target within a treatment fraction; and

compensating for baseline shift between treatment fractions based on the ITV.

2. The method of claim 1 , further comprising compensating for at least one of:, a setup error, a change in patient anatomy, or an intrafraction respiratory motion and baseline shift, based on the ITV.

3. The method of claim 1 , wherein the 4D inhale and exhale planning image is one of: a kilovoltage computed tomography (kV-CT) image, a magnetic resonance imaging (MRI) image, a kilovoltage cone beam computed tomography (kV-CBCT) image, or a megavoltage computed tomography (MVCT) image.

4. The method of claim 1 further comprising performing the volumetric alignment of the ITV and the non-target object including: performing two independent rigid registrations using determined registration regions of interest (ROI), or by deformable registration.

5. The method of claim 1 , wherein the reference image or the motion image are generated by an imaging source of a helical radiation delivery system or by one or more imaging sources at different positions with respect to a patient.

6. A system comprising:

a memory; and

a processing device, operatively coupled with the memory, to:

identify, based on a reference image, a full motion range of a target, wherein the full motion range of the target defines a full internal target volume (ITV), wherein the reference image is a four-dimensional (4D) inhale and exhale planning image;

identify a non-target object in a motion image or the reference image;

determine, based on a volumetric alignment of the ITV and the non-target object, a non-target to target displacement vector between a reference point on the non-target object and a center of the target defined by the reference image based on the volumetric alignment, wherein the non-target to target displacement vector defines an estimated relative position of the target with respect to the non-target object;

apply the same non-target to target displacement vector at the reference point on the non-target object after each of a plurality of non-target object corrections to perform 0-view tracking of the target indirectly based on the non-target to target displacement vector without tracking the target directly in the motion image, wherein the target displacement vector is to compensate for gross motion of the target within a treatment fraction; and

compensate for baseline shift between treatment fractions based on the ITV.

7. The system of claim 6 , wherein the processing device is further to compensate for at least one of: a setup error, a change in patient anatomy, or an intrafraction respiratory motion and baseline shift, based on the ITV.

8. The system of claim 6 , wherein the 4D inhale and exhale planning image is one of: a kilovoltage computed tomography (kV-CT) image, a magnetic resonance imaging (MRI) image, a kilovoltage cone beam computed tomography (kV-CBCT) image, or a megavoltage computed tomography (MVCT) image.

9. The system of claim 6 , wherein the processing device is further to perform the volumetric alignment of the ITV and the non-target object including to: perform two independent rigid registrations using determined registration regions of interest (ROI), or by deformable registration.

10. The system of claim 6 , wherein the reference image or the motion image are generated by an imaging source of a helical radiation delivery system or by one or more imaging sources at different positions with respect to a patient.

11. A non-transitory computer readable medium comprising instructions that, when executed by a processing device, cause the processing device to:

identify, based on a reference image, a full motion range of a target, wherein the full motion range of the target defines a full internal target volume (ITV);

identify a non-target object in a motion image or the reference image, wherein the motion image is a four-dimensional (4D) inhale and exhale intrafraction image;

determine, based on a volumetric alignment of the ITV and the non-target object, a non-target to target displacement vector between a reference point on the non-target object and a center of the target as defined by the reference image based on the volumetric alignment, wherein the non-target to target displacement vector defines an estimated relative position of the target with respect to the non-target object;

apply, by the processing device, the same non-target to target displacement vector at the reference point on the non-target object after each of a plurality of non-target object corrections to perform 0-view tracking of the target indirectly based on the non-target to target displacement vector without tracking the target directly in the motion image, wherein the target displacement vector is to compensate for gross motion of the target within a treatment fraction; and

compensate for baseline shift between treatment fractions based on the ITV.

12. The non-transitory computer readable medium of claim 11 , wherein the processing device is further to compensate for at least one of: a setup error, a change in patient anatomy, or an intrafraction respiratory motion and baseline shift, based on the ITV.

13. The non-transitory computer readable medium of claim 11 , wherein the reference image is a four-dimensional (4D) or a three-dimensional (3D) inhale and exhale planning image, and wherein the 4D inhale and exhale planning image is one of: a kilovoltage computed tomography (kV-CT) image, a magnetic resonance imaging (MRI) image, a kilovoltage cone beam computed tomography (kV-CBCT) image, or a megavoltage computed tomography (MVCT) image.

14. The non-transitory computer readable medium of claim 11 , wherein the reference image is a three-dimensional (3D) planning image, and wherein the 3D planning image is one of: a kilovoltage computed tomography (kV-CT) image, a magnetic resonance imaging (MRI) image, a kilovoltage cone beam computed tomography (kV-CBCT) image, or a megavoltage computed tomography (MVCT) image.

15. The non-transitory computer readable medium of claim 11 , wherein the processing device is further to perform the volumetric alignment of the ITV and the non-target object including to: perform two independent rigid registrations using determined registration regions of interest (ROI), or by deformable registration.

16. The non-transitory computer readable medium of claim 11 , wherein the non-target is a spine of a patient and wherein to track the target based on the modified non-target to target displacement vector, the processing device is to track gross patient motion with respect to the spine.

Assignments (10)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 13, 2025
From: ACCURAY INCORPORATED
To: ACCURAY LLC
Reel/Frame 072421/0584 →
RELEASE OF SECURITY INTEREST Recorded Jun 6, 2025
From: FIRST-CITIZENS BANK & TRUST COMPANY
To: ACCURAY INCORPORATED
Reel/Frame 071638/0034 →
RELEASE OF SECURITY INTEREST Recorded May 20, 2021
From: MIDCAP FINANCIAL TRUST
To: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
Reel/Frame 056301/0491 →
RELEASE OF SECURITY INTEREST Recorded May 20, 2021
From: MIDCAP FUNDING IV TRUST (AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FUNDING X TRUST, AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FUNDING IV TRUST, AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FINANCIAL TRUST)
To: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
Reel/Frame 056301/0432 →
SECURITY INTEREST Recorded May 14, 2021
From: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
To: SILICON VALLEY BANK, AS ADMINISTRATIVE AND COLLATERAL AGENT
Reel/Frame 056247/0001 →
ASSIGNMENT OF SECURITY AGREEMENTS Recorded Mar 1, 2019
From: MIDCAP FUNDING X TRUST (AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FUNDING IV TRUST, AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FINANCIAL TRUST), AS EXISTING ADMINISTRATIVE AGENT
To: MIDCAP FUNDING IV TRUST, AS SUCCESSOR TO EXISTING ADMINISTRATIVE AGENT
Reel/Frame 048481/0804 →
SECURITY INTEREST Recorded Jul 12, 2018
From: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
To: MIDCAP FUNDING X TRUST (AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FUNDING IV TRUST, AS SUCCESSOR BY ASSIGNMENT FROM MIDCAP FINANCIAL TRUST)
Reel/Frame 046336/0932 →
SECURITY INTEREST Recorded Jul 12, 2018
From: ACCURAY INCORPORATED; TOMOTHERAPY INCORPORATED
To: MIDCAP FINANCIAL TRUST
Reel/Frame 046337/0107 →
CORRECTIVE ASSIGNMENT TO CORRECT THE SECOND ASSIGNORS NAME PREVIOUSLY RECORDED AT REEL: 044981 FRAME: 0984. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT . Recorded Feb 22, 2018
From: JORDAN, PETR; MAURER, CALVIN R., JR.
To: ACCURAY INCORPORATED
Reel/Frame 046335/0005 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 20, 2018
From: JORDAN, PETR; MUARER, CALVIN R., JR.
To: ACCURAY INCORPORATED
Reel/Frame 044981/0984 →
Continuity (2)
Provisional Application 62443583 · Jan 6, 2017
Related Publication 20180193669A1 · Jul 12, 2018