Extrudable tubing for delivery of medicinal fluids

1. A method of coaxially bonding a polymeric tube ( 10 ) to a prefabricated tubular body ( 20 ), the prefabricated tubular body ( 20 ) defining a hollow central tubular passage ( 22 ) having a longitudinal axis bounded by an inner wall of polypropylene based material, the method comprising:

extruding a mating polymeric tube ( 10 ) having an outer tubular wall surface ( 18 ) comprising thermoplastic propylene-based elastomer (PBE) material, and a central tubular passage having a longitudinal axis and opposing ends,

treating the outer surface ( 18 ) of the mating tube ( 10 ) along a selected axial length at one of the end ( 11 ) of the tube ( 10 ) with a solvent that causes the treated outer surface ( 18 ) to adhere to the inner wall of the tubular body ( 20 ) on drying,

inserting the treated end ( 11 ) of the mating tube ( 10 ) coaxially into the central tubular passage ( 22 ) of the tubular body ( 20 ) such that the outer surface ( 18 ) of the treated end ( 11 ) mates with the inner wall of the tubular body ( 20 ) along the selected axial length to form a mated juncture,

allowing the mated juncture to dry such that the treated outer surface ( 18 ) solvent bonds to the inner wall,

wherein the solvent is selected from one or more of cyclohexanone, cyclohexane, hexane, xylene, tetrahydrofuran (THF), ethyl acetate (EA) and methyl ethyl ketone (MEK) and wherein the PBE is a blend of a first polymer component (FPC) which is a predominately crystalline stereoregular polypropylene, and a second polymer component (SPC) which is a crystallizable copolymer of C2, C4-C20 alpha-olefin and propylene.

2. The method of claim 1 wherein the tube ( 10 ) has an inner wall comprising a layer ( 14 ) of a polyethylene (PE).

3. The method of claim 2 wherein the PE of the inner wall is a low density polyethylene (LDPE), linear low density polyethylene (LLDPE), high density polyethylene (HDPE) or blends thereof.

4. The method of claim 1 wherein the step of extruding comprises coextruding an outer tubular layer ( 12 ) of the PBE material with at least one innermost tubular layer ( 14 ) of a thermoplastic ethylene-based olefinic material.

5. The method of claim 4 wherein the coextruded outer layer ( 12 ) of the mating tube ( 10 ) is the PBE material with an ethylene content of at least 9% by weight and the innermost layer ( 14 ) of the mating tube ( 10 ) is polyethylene.

6. The method of claim 1 wherein the tubular body ( 20 ) comprises a prefabricated body of PBE material.

7. The method of claim 6 wherein the PBE material of the tubular body ( 20 ) is a homopolymer polypropylene or a copolymer of predominately propylene units and ethylene.

8. A bonded tubular assembly comprising:

a prefabricated tubular body ( 20 ) defining a hollow central tubular passage ( 22 ) having a longitudinal axis bounded by an inner wall of propylene-based material,

an extruded tube ( 10 ) having an extruded outer tubular wall surface ( 18 ) comprising thermoplastic propylene-based elastomer (PBE) material, the mating tube ( 10 ) having a central tubular passage having a longitudinal axis and opposing ends,

wherein one of the ends ( 11 ) of the mating tube ( 10 ) is coaxially positioned within the central tubular passage ( 22 ) of the prefabricated tubular body ( 20 ) such that the outer surface ( 18 ) of the one end ( 11 ) of the mating tube ( 10 ) is mated with the inner wall of the tubular body ( 20 ) along a selected axial length of the mating tube ( 10 ),

the mated outer surface ( 18 ) and inner wall being solvent bonded to each other,

wherein the PBE is a blend of a first polymer component (FPC) which is a predominately crystalline stereoregular polypropylene, and a second polymer component (SPC) which is a crystallizable copolymer of C2, C4-C20 alpha-olefin and propylene.

9. The tubular assembly of claim 8 wherein the extruded tube ( 10 ) is a coextruded tube ( 10 ) having an outer tubular layer ( 12 ) of the PBE material with at least one innermost tubular layer ( 14 ) of a thermoplastic ethylene-based olefinic material.

10. The tubular assembly of claim 9 wherein the coextruded outer layer ( 12 ) of the mating tube ( 10 ) is the PBE material with an ethylene content of at least 9% by weight and the innermost layer ( 14 ) of the mating tube is polyethylene.

11. The tubular assembly of claim 8 wherein the tube ( 10 ) has an inner wall forming the central tubular passage comprising a coextruded layer of polyethylene (PE).

12. The tubular assembly of claim 11 , wherein the PE is a low density polyethylene (LDPE), linear low density polyethylene (LLDPE), high density polyethylene (HDPE) or blends thereof.

13. A method of delivering an aqueous based or non-aqueous based medicinal fluid or combination thereof to a patient comprising inserting a fluid delivery member into the body, the member being fluidly connected to the bonded tubular assembly of claim 8 , and delivering the medical fluid through the tube ( 10 ) to the delivery member.

14. The method of claim 13 , wherein the medicinal fluid comprises one or more of:

the nonaqueous solvents selected from the group consisting of: vegetable oils, ethyl oleate, propylene glycol, and polyethylene glycols with molecular weights of 300 and 400.

15. The method of claim 13 , wherein the medicinal fluid comprises one or more of:

synthetic and semisynthetic preparations as solvent or mixed solvent based fluid preparations for injection to the patient, selected from the group consisting of alcohols, esters, ethers, amides, sulfoxides and pyrrolidones, optionally wherein the fluid preparations are selected form the group consisting of ethyl alcohol; benzyl alcohol;

phenylethyl alcohol; propylene glycol; butylene glycol; trichloro-t-butyl; polyoxyethylene glycol; ethyl ether; phenoxyethanol; ethyl acetate ethyl oleate; benzyl benzoate; N-methylacetamide; N,N-dimethylacetamide; dimethyl sulfoxide (DMSO), and N-methyl 2-pyrrolidone (NMP).