IP Library Granted Patent US 10,821,228
Granted Patent B2
US 10,821,228 · App. 15/870,609 · Granted Nov 3, 2020

System and method for adjusting insulin delivery

Inventors: Bryan Mazlish (Palo Alto, CA); Lane Desborough (Thousand Oaks, CA); Ross Naylor (Fullerton, CA)
Assignee: Bigfoot Biomedical, Inc.
A61M5/1723A61B5/14532A61M5/14248G16H20/17G16H40/60A61B5/4839A61K38/28A61M5/003A61M5/31568A61M2205/35A61M2205/502A61M2205/52A61M2230/201
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Quick Facts
Patent No.
US 10,821,228
App. No.
15/870,609
Granted
Nov 3, 2020
Kind
B2
Abstract

The embodiments described herein may relate to methods and systems for adjusting insulin delivery. Some methods and systems may be configured to adjust insulin delivery to personalize automated insulin delivery for a person with diabetes. Such personalization may include adjusting user specific dosage parameters in response to a user provided insulin delivery amount, including a user provided insulin delivery amount that varies from a recommended insulin delivery amount.

Claims (55)

1. A method, comprising:

receiving a user specified bolus dose of insulin that is different than a recommended bolus dose of insulin;

determining a meal component of the user specified bolus dose of insulin;

adjusting one or more user specific dosage parameters based on the determined meal component;

determining a future blood glucose level for a time interval based on the adjusted one or more user specific dosage parameters;

determining a basal insulin delivery for the time interval based on the determined future blood glucose level; and

configuring an insulin delivery system to deliver insulin during the time interval according to the determined basal insulin delivery.

2. The method of claim 1 , wherein determining a meal component of the user specified bolus dose of insulin comprises determining a carbohydrate blood glucose level by subtracting a correction blood glucose level from the user specified bolus dose of insulin, wherein the correction component is associated with the recommended bolus dose of insulin.

3. The method of claim 1 , further comprising determining future blood glucose levels for a number of insulin delivery profiles.

4. The method of claim 3 , wherein each insulin delivery profile comprises:

the time interval, wherein the time interval is defined by a start time, an end time, and a number of sub-time intervals between the start time and the end time, and

one or more insulin delivery actions, wherein each of the one or more insulin delivery actions is associated with a sub-time interval of the number of sub-time intervals.

5. The method of claim 4 , further comprising selecting an insulin delivery profile responsive to a comparison of the determined future blood glucose levels and one or more target blood glucose levels.

6. The method of claim 4 , wherein the time interval is a diurnal time interval.

7. The method of claim 1 , wherein the one or more user specific dosage parameters are selected from a group comprising: a carbohydrate to insulin ratio, an insulin sensitivity factor, and a daily basal rate.

8. The method of claim 1 , wherein the one or more user specific dosage parameters is are an amount of carbohydrates.

9. The method of claim 8 , wherein the amount of carbohydrates is grams of carbohydrates.

10. The method of claim 1 , further comprising:

determining an automated correction insulin delivery based on the one or more user specific dosage parameters; and

configuring the insulin delivery system to deliver insulin during the time interval according to the determined automated correction insulin delivery.

11. An insulin delivery system, comprising:

an insulin delivery device configured to deliver insulin to a user of the insulin delivery system;

a processing unit associated with the insulin delivery device, the processing unit configured to:

determine a meal component of a user specified bolus dose of insulin;

adjust one or more user specific dosage parameters based on the determined meal component;

determine a future blood glucose level for a time interval based on the adjusted one or more user specific dosage parameters;

determine a basal insulin delivery for the time interval based on the determined future blood glucose level; and

configure the insulin delivery device to deliver insulin during the time interval according to the determined basal insulin delivery.

12. The system of claim 11 , wherein the one or more user specific dosage parameters are selected from a group comprising: a carbohydrate to insulin ratio, an insulin sensitivity factor, and a daily basal rate.

13. The system of claim 11 , wherein the one or more user specific dosage parameters is an are an amount of carbohydrates.

14. The system of claim 13 , wherein the amount of carbohydrates is grams of carbohydrates.

15. The system of claim 11 , further comprising a memory having stored thereon a number of insulin delivery profiles.

16. The system of claim 15 , wherein each insulin delivery profile comprises:

the time interval, wherein the time interval is defined by a start time, an end time, and a number of sub-time intervals between the start time and the end time, and

one or more insulin delivery actions, wherein each of the one or more insulin delivery actions is associated with a sub-time interval of the number of sub-time intervals.

17. The system of claim 15 , wherein the “processing unit” is further configured to determine future blood glucose levels for a number of insulin delivery profiles.

18. The system of claim 15 , wherein the “processing unit” is further configured to select an insulin delivery profile responsive to a comparison of the determined future blood glucose levels and one or more target blood glucose levels.

19. The system of claim 15 , wherein the insulin delivery device is configured to deliver insulin automatically.

20. A method, comprising:

displaying a dashboard comprising a number of display regions and a number of activatable regions, wherein the number of display regions are configured to display information to a user of an insulin delivery system, and further wherein the number of activatable regions are configured to permit the user to interact with the insulin delivery system;

providing a first insulin delivery schedule at a first display region;

providing a recommended bolus dose of insulin at a second display region;

receiving a user recommended bolus dose of insulin at a first activatable region, the user recommended bolus dose of insulin being different than the recommended bolus dose of insulin; and

providing a second insulin delivery schedule at the first display region, the second insulin delivery schedule associated with the user recommended bolus dose of insulin.

21. The method of claim 20 , wherein each of the first insulin delivery schedule and the second insulin delivery schedule comprises:

at least one time interval having a start time, an end time, and a number of sub-time intervals between the start time and the end time; and

insulin delivery levels associated with the number of sub-time intervals.

22. The method of claim 21 , wherein the at least one time interval is a diurnal time interval.

23. The method of claim 20 , further comprising:

providing a user specific dosage parameter at a third display region; and

providing an adjusted user specific dosage parameter at the third display region.

24. The method of claim 23 , wherein the user specific dosage parameter is selected from the group consisting of a carbohydrate to insulin ratio, an insulin sensitivity factor, and a daily basal rate.

25. The method of claim 24 , wherein the user specified dosage parameter is an amount of carbohydrates.

26. The method of claim 25 , wherein the amount of carbohydrates is grams of carbohydrates.

27. The method of claim 20 , further comprising providing future blood glucose levels associated with at least one time interval at a third display region.

Assignments (16)
SECURITY INTEREST Recorded Jan 10, 2025
From: MADRYN HEALTH PARTNERS, LP
To: MADRYN FUND ADMINISTRATION, LLC
Reel/Frame 069870/0519 →
SECURITY INTEREST Recorded Jan 10, 2025
From: BIGFOOT BIOMEDICAL, INC.
To: MADRYN HEALTH PARTNERS, LP
Reel/Frame 069870/0456 →
SECURITY INTEREST Recorded Sep 30, 2024
From: MADRYN HEALTH PARTNERS, LP
To: MADRYN FUND ADMINISTRATION, LLC
Reel/Frame 069074/0001 →
SECURITY INTEREST Recorded Sep 30, 2024
From: BIGFOOT BIOMEDICAL, INC.
To: MADRYN HEALTH PARTNERS, LP
Reel/Frame 069073/0912 →
SECURITY INTEREST Recorded Sep 24, 2024
From: MADRYN HEALTH PARTNERS, LP
To: MADRYN FUND ADMINISTRATION, LLC
Reel/Frame 069030/0104 →
SECURITY INTEREST Recorded Sep 24, 2024
From: BIGFOOT BIOMEDICAL, INC.
To: MADRYN HEALTH PARTNERS, LP
Reel/Frame 069030/0296 →
SECURITY INTEREST Recorded Sep 23, 2024
From: BIGFOOT BIOMEDICAL, INC.
To: MADRYN HEALTH PARTNERS, LP
Reel/Frame 069019/0142 →
SECURITY INTEREST Recorded Sep 23, 2024
From: MADRYN HEALTH PARTNERS, LP
To: MADRYN FUND ADMINISTRATION, LLC
Reel/Frame 069019/0188 →
SECURITY INTEREST Recorded Sep 12, 2024
From: MADRYN HEALTH PARTNERS, LP
To: MADRYN FUND ADMINISTRATION, LLC
Reel/Frame 068948/0324 →
SECURITY INTEREST Recorded Sep 12, 2024
From: BIGFOOT BIOMEDICAL, INC.
To: MADRYN HEALTH PARTNERS, LP
Reel/Frame 068948/0172 →
SECURITY AGREEMENT SUPPLEMENT Recorded Sep 7, 2023
From: INSULET CORPORATION
To: MORGAN STANLEY SENIOR FUNDING, INC., AS COLLATERAL AGENT
Reel/Frame 064840/0181 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 1, 2023
From: BIGFOOT BIOMEDICAL, INC.
To: INSULET CORPORATION
Reel/Frame 062900/0001 →
RELEASE OF SECURITY INTEREST Recorded Feb 17, 2023
From: MADRYN FUND ADMINISTRATION, LLC
To: BIGFOOT BIOMEDICAL, INC.
Reel/Frame 062793/0316 →
SECURITY INTEREST Recorded Feb 10, 2023
From: MADRYN HEALTH PARTNERS, LP
To: MADRYN FUND ADMINISTRATION, LLC
Reel/Frame 062702/0145 →
SECURITY INTEREST Recorded Mar 12, 2021
From: BIGFOOT BIOMEDICAL, INC.
To: MADRYN HEALTH PARTNERS, LP
Reel/Frame 055583/0044 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Oct 8, 2018
From: MAZLISH, BRYAN; DESBOROUGH, LANE; NAYLOR, ROSS
To: BIGFOOT BIOMEDICAL, INC.
Reel/Frame 047097/0094 →