Powder delivery devices

1. A method of delivering powdered substance to a nasal cavity of a subject, the method comprising:

rupturing a powdered substance-containing container within a substance supply unit of a delivery device, wherein the delivery device comprises:

the substance supply unit for supplying a dose of powdered substance to be delivered to the nasal cavity of the subject, the substance supply unit including an inlet and an outlet;

a nosepiece unit including a nosepiece for fitting to the nasal cavity of the subject and being in fluid communication with the outlet of the substance supply unit; and

a mouthpiece unit including a mouthpiece in fluid communication with the inlet of the substance supply unit and through which the subject in use exhales such as to entrain powdered substance from the substance supply unit and deliver the same through the nosepiece;

wherein the substance supply unit comprises a container chamber for receiving the powdered substance-containing container which contains a dose of powdered substance, and the container or an outer coating on a body of the container is formed of a material which exhibits insufficient tackiness in the presence of moisture so as not to adhere to an inner surface of the container chamber during emptying of the powdered substance from the container;

fitting the nosepiece unit of the delivery device to the nasal cavity of the subject; and

the subject exhaling through the mouthpiece unit such as to entrain powdered substance from the substance supply unit and deliver the same through the nosepiece to the nasal cavity of the subject.

2. The method of claim 1 , wherein the container chamber is substantially cylindrical in shape or substantially spherical in shape.

3. The method of claim 1 , wherein the substance supply unit comprises a rupturing mechanism for rupturing the container as contained in the container chamber.

4. The method of claim 1 , wherein the container or the outer coating of the container is formed of a material which exhibits insufficient tackiness in the presence of moisture in the exhalation air flow for a period of (i) up to about 5 s following exhalation, (ii) up to about 2 s following exhalation, or (iii) up to about 1 s following exhalation.

5. The method of claim 4 , wherein the container or the body of the container is formed substantially of a cellulose derivative, optionally one or more of hydroxypropyl methylcellulose (HPMC), hydroxypropylcellulose, methylcellulose, ethylcellulose and carboxymethylcellulose.

6. The method of claim 4 , wherein the coating comprises substantially one of parylene, hydroxypropyl methylcellulose (HPMC), hydroxypropylcellulose, methylcellulose, ethylcellulose, carboxymethylcellulose, polyvinyl alcohol, acrylic acid polymer, methacrylic acid polymer, ethyl acrylic acid polymer, cellulose acetate phthalate, polyvinyl acetate phthalate, hydroxypropyl methylcellulose phthalate and hydroxyl methylcellulose acetate succinate, or any combination of layers thereof.

7. The method of claim 1 , wherein the container comprises a capsule, optionally the capsule is substantially cylindrical in shape or substantially spherical in shape.

8. The method of claim 1 , wherein the powdered substance is a hygroscopic powder.

9. The method of claim 1 , wherein the container or the body of the container comprises a cellulose derivative.

10. The method of claim 1 , wherein the container or the body of the container comprises hydroxypropyl methylcellulose (HPMC).

11. The method of claim 1 , wherein the container or the body of the container comprises one or more of hydroxypropylcellulose, methylcellulose, ethylcellulose and carboxymethylcellulose.

12. The method of claim 1 , wherein the container or the body of the container comprises methylcellulose.

13. The method of claim 1 , wherein the container or the body of the container comprises ethylcellulose.

14. The method of claim 1 , wherein the container or the body of the container comprises carboxymethylcellulose.