Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-deltaC virus) in cancer therapy
The invention relates to a genetically modified infectious measles virus derived from a live-attenuated measles virus strain, in which the gene encoding the viral accessory C protein has been knocked out (MV-deltaC). It concerns in particular the use of said genetically modified infectious MV-deltaC in the treatment of malignant tumor or cancer conditions, and for the preparation of agents or compositions for such treatment.
1. A method of treating lung adenocarcinoma in a subject in need thereof, comprising administering an effective amount of an infectious live-attenuated measles virus (MV) strain to the subject, wherein the gene encoding the viral accessory C protein has been knocked out in the infectious live-attenuated MV (MV-deltaC).
2. The method of claim 1 , wherein administering the infectious live-attenuated MV to the subject activates plasmacytoid dendritic cells (pDCs).
3. The method of claim 1 , wherein the lung adenocarcinoma is resistant to infectious live-attenuated MV comprising a functional gene encoding the viral accessory C protein.
4. The method of claim 1 , wherein the live-attenuated measles virus strain is the Schwarz strain or the Moraten strain.
5. The method of claim 1 , wherein administering the infectious live-attenuated MV to the subject induces cell death of lung adenocarcinoma cells.
6. The method of claim 1 , wherein administering the infectious live-attenuated MV to the subject reduces lung adenocarcinoma tumor volume.