Foamable vehicles and pharmaceutical compositions comprising aprotic polar solvents and uses thereof
View Patent ↗The present invention teaches a foamable pharmaceutical and cosmetic compositions comprising an aprotic polar solvent; foam compositions and uses thereof.
1. A non-aqueous composition formulated for skin delivery of an active agent comprising:
a minocycline in a therapeutically effective amount of about 1% to about 5% by weight of the composition;
a short chain alcohol comprising ethanol present in an amount of at least 55% by weight of the composition;
about 12% to about 50% by weight of the composition of a protic polar solvent comprising propylene glycol;
a polymeric agent comprising a cellulose ether, wherein the cellulose ether is a hydroxypropyl cellulose present in an amount ranging from about 0.5% to about 1% by weight of the composition;
a modulating agent comprising an antioxidizing agent present in an amount ranging from about 0.1% to about 10% by weight of the composition;
a metal; and
an essential oil,
wherein the composition is surfactant free, non-aqueous, and free or essentially free of fatty alcohol.
2. The non-aqueous composition according to claim 1 , wherein the minocycline is dissolved in the composition.
3. The non-aqueous composition according to claim 2 , wherein the minocycline is a minocycline hydrochloride.
4. The non-aqueous composition according to claim 1 , wherein the protic polar solvent is about 12% to about 30% by weight of the composition.