Amides of acetic and propionic acids
The invention relates to novel amides of acetic and propionic acids, methods for production and use thereof for the production of medicaments for the treatment and/or prophylaxis of diseases and for improving perception, concentration, learning ability and memory.
1. A method of improving perception, concentration, learning or memory, after a cognitive impairment in a patient in need thereof, comprising administering to the patient a compound selected from the group consisting of:
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(7-bromo-1-benzothien-2-yl) acetamide hydrochloride;
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(6-bromo-1-benzothien-2-yl) acetamide hydrochloride;
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(7-quinolinyl) acetamide hydrochloride;
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(2-naphthyl)acetamide hydrochloride; and
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(8-nitro-2-naphthyl) acetamide hydrochloride.
2. The method of claim 1 , wherein the cognitive impairment is mild cognitive impairment or Alzheimer's disease.
3. The method of claim 1 , wherein the cognitive impairment is schizophrenia or schizophrenia with dementia.
4. The method of claim 1 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(7-bromo-1-benzothien-2-yl)acetamide hydrochloride.
5. The method of claim 1 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(6-bromo-1-benzothien-2-yl)acetamide hydrochloride.
6. The method of claim 1 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(7-quinolinyl)acetamide hydrochloride.
7. The method of claim 1 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(2-naphthyl)acetamide hydrochloride.
8. The method of claim 1 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(8-nitro-2-naphthyl)acetamide hydrochloride.
9. A method of treating a patient suffering from a cognitive impairment in a patient in need thereof, comprising administering to the patient a compound selected from the group consisting of:
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(7-bromo-1-benzothien-2-yl)acetamide hydrochloride;
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(6-bromo-1-benzothien-2-yl)acetamide hydrochloride;
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(7-quinolinyl)acetamide hydrochloride;
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(2-naphthyl)acetamide hydrochloride; and
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(8-nitro-2-naphthyl)acetamide hydrochloride,
wherein the cognitive impairment is selected from the group consisting of: mild cognitive impairment, Alzheimer's disease, schizophrenia, and schizophrenia with dementia.
10. The method of claim 9 , wherein the cognitive impairment is mild cognitive impairment or Alzheimer's disease.
11. The method of claim 9 , wherein the cognitive impairment is schizophrenia or schizophrenia with dementia.
12. The method of claim 9 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(7-bromo-1-benzothien-2-yl)acetamide hydrochloride.
13. The method of claim 9 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(6-bromo-1-benzothien-2-yl)acetamide hydrochloride.
14. The method of claim 9 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(7-quinolinyl)acetamide hydrochloride.
15. The method of claim 9 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(2-naphthyl)acetamide hydrochloride.
16. The method of claim 9 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(8-nitro-2-naphthyl)acetamide hydrochloride.
17. A method of treating a patient suffering from a cognitive impairment in a patient in need thereof, comprising administering to the patient a pharmaceutical composition comprising:
i) a compound selected from the group consisting of:
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(7-bromo-1-benzothien-2-yl) acetamide hydrochloride;
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(6-bromo-1-benzothien-2-yl) acetamide hydrochloride;
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(7-quinolinyl) acetamide hydrochloride;
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(2-naphthyl)acetamide hydrochloride; and
2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(8-nitro-2-naphthyl) acetamide hydrochloride; and
ii) one or more pharmaceutically acceptable carriers or excipients,
wherein the cognitive impairment is selected from the group consisting of: mild cognitive impairment, Alzheimer's disease, schizophrenia, and schizophrenia with dementia.
18. The method of claim 17 , wherein the cognitive impairment is mild cognitive impairment or Alzheimer's disease.
19. The method of claim 17 , wherein the cognitive impairment is schizophrenia.
20. The method of claim 17 , wherein the cognitive impairment is schizophrenia with dementia.
21. The method of claim 17 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(7-bromo-1-benzothien-2-yl)acetamide hydrochloride.
22. The method of claim 17 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(6-bromo-1-benzothien-2-yl)acetamide hydrochloride.
23. The method of claim 17 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(7-quinolinyl)acetamide hydrochloride.
24. The method of claim 17 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(2-naphthyl)acetamide hydrochloride.
25. The method of claim 17 , wherein the compound is 2-(1-azabicyclo[2.2.2]oct-3-yl)-N-(8-nitro-2-naphthyl)acetamide hydrochloride.